Research on the Drug's Potential of Intrinsically Disordered Proteins

DOI

10.2991/ammee-17.2017.134How to use a DOI?

Keywords

Intrinsically disordered proteins, drug design, drug targets, and molecular recognition.

Abstract

Intrinsically Disordered Proteins (IDPs) are a class of proteins that have no sure tertiary or secondary structure in the natural state. They are widely found in nature and involved in cell signal transduction, regulation, and protein interactions with a wide range of human diseases related. The research of IDPs provides new opportunities for drug design, and many cancer-related diseases are associated with IDPs lacking of ordered structures. However, the structural dynamic properties of IDPs present a significant obstacle to directly targets for drug design due to lacking of ordered structures in IDPs. This paper reviews the current research on the drug design progress of IDPs, lists examples on the drug design of IDPs, and some potential drug targets that can be used in IDPs. Finally, it analyzes the obstacles and difficulties in the drug design of IDPs.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Peilun Jiang
PY  - 2017/06
DA  - 2017/06
TI  - Research on the Drug's Potential of Intrinsically Disordered Proteins
BT  - Proceedings of the Advances in Materials, Machinery, Electrical Engineering (AMMEE 2017)
PB  - Atlantis Press
SP  - 698
EP  - 701
SN  - 2352-5401
UR  - https://doi.org/10.2991/ammee-17.2017.134
DO  - 10.2991/ammee-17.2017.134
ID  - Jiang2017/06
ER  -