Anti-fatigue Properties of Icariin Isolated from Epimedium Brevicornum Maxim in Mice

DOI

10.2991/aeece-16.2016.32How to use a DOI?

Keywords

icariin; anti-fatigue; forced swimming test; exhaustive swimming times; mice.

Abstract

Aim of the present study was to evaluate the anti-fatigue properties of icariin in mice. The animals were divided into four groups, namely the control, low-dose icariin treated, medium-dose icariin treated, and high-dose icariin treated groups, which received distilled water and 5, 10 and 20 mg/kg icariin, respectively, by oral gavage. After 28 days, the forced swimming test was performed, along with the determination of blood lactic acid (BLA), serum urea nitrogen (SUN), superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). The results showed that icariin could extend the exhaustive swimming times, as well as decrease the BLA, SUN and serum MDA levels, while increasing the serum SOD and GPx levels. Thus, the results demonstrated that icariin has anti-fatigue properties.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Changjun Li
AU  - Ang Li
PY  - 2016/07
DA  - 2016/07
TI  - Anti-fatigue Properties of Icariin Isolated from Epimedium Brevicornum Maxim in Mice
BT  - Proceedings of the 2016 2nd International Conference on Advances in Energy, Environment and Chemical Engineering (AEECE 2016)
PB  - Atlantis Press
SP  - 146
EP  - 149
SN  - 2352-5401
UR  - https://doi.org/10.2991/aeece-16.2016.32
DO  - 10.2991/aeece-16.2016.32
ID  - Li2016/07
ER  -