Optimization of Nanoemulgel Formula of Gold Particle-Vitamin E and in Vivo Test

DOI

10.2991/adics-phs-19.2019.1How to use a DOI?

Keywords

SNEDDS, Gold, vitamine E, Skin Regenerate, Design Optimum Introduction

Abstract

Gold is a substance that can be used as a collagen forming catalyst, it can help regenerate the skin. Vit.E is a natural antioxidant compound that can be used to help regenerate and brighten the skin. Gold is a metal so it is difficult to apply into the skin. Gold and vit.E are formulated with SNEDDS (Self Nano Emulsifying Drugs Delivery System) technique, in order to reduce the size and dispersing of gold particles homogeneously. SNEDDS formula consists of olive oil, tween 80 (surfactant), propylene glycol (co-surfactant), vit.E and gold particles, which are optimized to obtain the optimum component using the D-Optimal method. Software will obtaine 16 run formulas with difference composition of olive oil, tween 80, and propylene glycol. Transmittance value and pH as respons. Loading dose capability was also carried out. Verification with statistical analysis using one sample t-test and then evaluated particle size, polydispersity index, and zeta potential. SNEDDS gold-Vit E optimum formula then dispersed into matrix hydrogel (Carbopol). The formula of Nanoemulgel gold was evaluated for physical properties and in vivo tests compared with brand gold cosmetic. The optimum composition of olive oil (9,09%), tween 80 (80,62%), and propylene glycol (10,29%) with loading dose of 2,6 mg gold and 250 µL of vitamin E. Characterization results showed the transmittance value is 97,22±0,06% and pH is 6,72±0,04 which shows no significant difference (p> 0,05) between the observation and software prediction. The results of SNEDDS evaluation showed a particle size of 150,2 nm, PI of -0,52 and potential zeta -24,9 mV. The results of stability test of nanoemulgel showed a semisolid, broken white colour, transparent, odorless, homogeneous. pH value of 6,78±0,06; viscosity of 346,67±15,27 dPas; and spread test of 5,48±0,035 cm. The results of the in vivo test showed that on the 6th day there was a significant skin regeneration when compared to brand product

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Dian Eka Ermawati
AU  - Fildza Alya I
AU  - Fea Prihapsara
PY  - 2019/11
DA  - 2019/11
TI  - Optimization of Nanoemulgel Formula of Gold Particle-Vitamin E and in Vivo Test
BT  - Proceedings of the 2019 Ahmad Dahlan International Conference Series on Pharmacy and Health Science (ADICS-PHS 2019)
PB  - Atlantis Press
SP  - 142
EP  - 146
SN  - 2468-5739
UR  - https://doi.org/10.2991/adics-phs-19.2019.1
DO  - 10.2991/adics-phs-19.2019.1
ID  - Ermawati2019/11
ER  -