Journal of Risk Analysis and Crisis Response

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Volume 3, Issue 4, December 2013, Pages 175 - 184

Internal Exposure Simulation Based on Exposure Related Dose Estimating Model

Authors
Qian Zhang, Deyin Huang, Mao Liu, Minyan Li
Corresponding Author
Qian Zhang
Received 28 August 2013, Accepted 12 December 2013, Available Online 27 December 2013.
DOI
10.2991/jrarc.2013.3.4.3How to use a DOI?
Keywords
physiologically based pharmacokinetic model, exposure related dose estimating model, internal exposure, occupational cancer risk
Abstract

n this paper, occupational chemical poisons’ physiologically based pharmacokinetic (PBPK) models are established to simulate metabolic processes in vivo based on exposure simulation software- exposure related dose estimating model (ERDEM). PBPK model establishing progress is described based on the development and utilization of ERDEM. As well known, benzene, 1, 3-butadiene and vinyl chloride are definitely carcinogenic to humans. The study on these carcinogens’ internal exposure has important significance to carcinogenic risk. Internal exposure of these three kinds of chemicals are simulated with parameters of PBPK model, organizations and organism from literature data, which proves ERDEM’s broad applicability. Simulation results are represented by different kinds of results forms such as toxicant concentration in blood changes over time, toxicant average concentration in blood, metabolite amount in target organ changes over time, toxicant concentration in exhaled air changes over time and so on. And the simulation results are verified by comparing with the experimental results in previous literature. The good consistency between simulation results and experimental date reflects that output results of ERDEM are reliable and can be characterized in various forms.

Copyright
© 2013, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Journal of Risk Analysis and Crisis Response
Volume-Issue
3 - 4
Pages
175 - 184
Publication Date
2013/12/27
ISSN (Online)
2210-8505
ISSN (Print)
2210-8491
DOI
10.2991/jrarc.2013.3.4.3How to use a DOI?
Copyright
© 2013, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Qian Zhang
AU  - Deyin Huang
AU  - Mao Liu
AU  - Minyan Li
PY  - 2013
DA  - 2013/12/27
TI  - Internal Exposure Simulation Based on Exposure Related Dose Estimating Model
JO  - Journal of Risk Analysis and Crisis Response
SP  - 175
EP  - 184
VL  - 3
IS  - 4
SN  - 2210-8505
UR  - https://doi.org/10.2991/jrarc.2013.3.4.3
DO  - 10.2991/jrarc.2013.3.4.3
ID  - Zhang2013
ER  -