MCSim-Based Occupational Health Risk Assessment on Benzene

DOI

10.2991/jrarc.2013.3.3.3How to use a DOI?

Keywords

Health risk assessment, Benzene occupational exposure, Physiologically based pharmacokinetic model, Dose-response relationship, MCSim software

Abstract

Nowadays, the acute and chronic adverse health effects caused by benzene exposure have attracted wide attention. In this paper, we evaluate the health risk based on the four-step method recommended by U.S. Environmental Protection Agency (USEPA). We present a method using the Monte Carlo Simulating Software (MCSim) to build a PBPK model to simulate the concentrations in target tissues of human in distribution forms. The internal dose will be used in the dose-response model to figure out the cancer risk. In the case of workers exposed to benzene in oil refinery workplace, we take the advantage of FLUENT software to simulate the external dose, treat the concentration data by SPSS, and compute the internal dose by MCSim software, so that the lifetime cancer risk range of exposed workers can be calculated if the benzene occupational exposure scenarios are complicated. This method will be used to provide the basis for the occupation health management of enterprises.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Minyan Li
AU  - Deyin Huang
AU  - Mao Liu
PY  - 2013
DA  - 2013/11/01
TI  - MCSim-Based Occupational Health Risk Assessment on Benzene
JO  - Journal of Risk Analysis and Crisis Response
SP  - 135
EP  - 145
VL  - 3
IS  - 3
SN  - 2210-8505
UR  - https://doi.org/10.2991/jrarc.2013.3.3.3
DO  - 10.2991/jrarc.2013.3.3.3
ID  - Li2013
ER  -