Study of drug resistance in pulmonary tuberculosis cases in south coastal Karnataka

Parashuram Rao; Kiran Chawla; Vishnu Prasad Shenoy; Chiranjay Mukhopadhyay; Vishwanath Brahmavar; Asha Kamath; Aswini Kumar Mohapatra

doi:10.1016/j.jegh.2015.01.002

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Volume 5, Issue 3, September 2015, Pages 275 - 281

Study of drug resistance in pulmonary tuberculosis cases in south coastal Karnataka

Authors

Parashuram Rao^a, Kiran Chawla^a^{, *}^,arunkiranchawla@yahoo.com, Vishnu Prasad Shenoy^a, Chiranjay Mukhopadhyay^a, Vishwanath Brahmavar^b, Asha Kamath^c, Aswini Kumar Mohapatra^d

^aDepartment of Microbiology, Kasturba Medical College, Manipal, Manipal University, Karnataka 576104, India

^bDistrict Tuberculosis Office, Behind DHO Office, Ajjarkadu Hospital Premises, Udupi, Karnataka 576101, India

^cDepartment of Community Medicine, Kasturba Medical College, Manipal, Manipal University, Karnataka 576104, India

^dDepartment of Pulmonary Medicine, Kasturba Medical College, Manipal, Manipal University, Karnataka 576104, India

^*Corresponding author.

Corresponding Author

Kiran Chawlaarunkiranchawla@yahoo.com

Received 20 November 2014, Revised 15 January 2015, Accepted 18 January 2015, Available Online 14 February 2015.

DOI: 10.1016/j.jegh.2015.01.002 How to use a DOI?
Keywords: India; Pulmonary tuberculosis; Drug resistance
Abstract: The present cross-sectional study was conducted for the first time from the Udupi district of coastal Karnataka to know the prevalence of drug resistance and comparative analysis of MDR and non-MDR cases of pulmonary tuberculosis. Details of 862 smear positive cases of pulmonary tuberculosis with age ⩾15 years from 12 designated microscopy centres of the Udupi district were studied. Initially 2 sputum samples trailed by one follow-up sample were collected from each patient and processed for culture and drug sensitivity on the Lowenstein-Jensen medium. A total resistance of 33.4% was observed that includes the mono-resistance of 22.5%, multidrug resistance (MDR) of 6.3% and extensive drug resistance (XDR) of 0.3%. Significant odds ratio (OR) was observed in category 2 cases (OR 3.9) for the development of MDR tuberculosis. A significant statistical association was observed using Fisher’s exact test while comparing mortality rate (19.3% vs. 1.8%), treatment failure (8.8% vs. 3.8%) and cure rate (68.4% vs. 85.4%) between MDR and non-MDR cases (p < 0.001). Category 2 patients are important risk factors for the development of MDR in pulmonary tuberculosis. Due to high mortality and low cure rate in MDR cases it is imperative to know the drug sensitivity report before institution of anti-tubercular treatment.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 5 - 3
Pages: 275 - 281
Publication Date: 2015/02/14
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2015.01.002 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Parashuram Rao
AU  - Kiran Chawla
AU  - Vishnu Prasad Shenoy
AU  - Chiranjay Mukhopadhyay
AU  - Vishwanath Brahmavar
AU  - Asha Kamath
AU  - Aswini Kumar Mohapatra
PY  - 2015
DA  - 2015/02/14
TI  - Study of drug resistance in pulmonary tuberculosis cases in south coastal Karnataka
JO  - Journal of Epidemiology and Global Health
SP  - 275
EP  - 281
VL  - 5
IS  - 3
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2015.01.002
DO  - 10.1016/j.jegh.2015.01.002
ID  - Rao2015
ER  -

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