Comparison of Tuberculin Skin Test result and interferon gamma response to human PPD in BCG scar positive and negative children

Shirin Sayyahfar; Abdollah Karimi; Alireza Fahimzad; Ahmad Reza Shamshiri

doi:10.1016/j.jegh.2013.09.002

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Comparison of Tuberculin Skin Test result and interferon gamma response to human PPD in BCG scar positive and negative children

Authors

Shirin Sayyahfar^a^{, *}^,sayyahfar.sh@iums.ac.ir sayyahfar_shirin@yahoo.com, Abdollah Karimi^b, Alireza Fahimzad^b, Ahmad Reza Shamshiri^c

^aDivision of Pediatric Infectious Diseases, Department of Pediatrics, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

^bDivision of Pediatric Infectious Diseases, Pediatric Infectious Research Center(PIRC), Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

^cDentistry Research Institute, Department of Community Oral Health, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

^*Corresponding author. Address: Division of Pediatric Infectious Diseases, Department of Pediatrics, Iran University of Medical Sciences, Ali Asghar Children Hospital, Vahid Dastgerdi Street, Shariati Street, Tehran 1919816766, Iran. Tel.: +98 21 22255218; fax: +98 21 22220063.

Corresponding Author

Shirin Sayyahfarsayyahfar.sh@iums.ac.ir sayyahfar_shirin@yahoo.com

Received 6 May 2013, Revised 1 September 2013, Accepted 3 September 2013, Available Online 9 October 2013.

DOI: 10.1016/j.jegh.2013.09.002 How to use a DOI?
Keywords: BCG vaccine; Human PPD; Interferon Gamma Release Assay; Tuberculin Skin Test; Vaccine scar
Abstract: Background: The aim of this study is to compare Tuberculin Skin Test (TST) result and interferon gamma response to human PPD (purified protein derivative), in scar positive and scar negative BCG-vaccinated children.

Methods: Between August 2007 and May 2008 a total of 236 children aged 1–168 months (mean 21 months) admitted to Mofid Children’s Hospital, Tehran, Iran, were enrolled in a cross-sectional study. Each patient was examined for BCG vaccine scar and tested with TST and human PPD-based Interferon Gamma Release Assay (IGRA).

Results: Two hundred and twenty one cases out of 236 (44% female, 1–168 months, mean age 21 months) were scar positive of whom 95% TST result was negative. Human PPD-based IGRA was positive in 110 (49.8%), negative in 85 (38.4 %) and indeterminate in 26 (11.8%) of scar positive patients.

Fifteen children (40% female, 1–156 months; mean age 42 months) were scar negative. All the scar negative cases were TST negative. Human PPD-based IGRA was positive in 10 (66.7%), negative in 4 (26.7%) and indeterminate in 1 (6.7%) of scar negative patients.

Conclusions: Immune responsiveness to human PPD antigens in scar positive and negative children may not correspond with results of the Tuberculin Skin Test.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 4 - 1
Pages: 45 - 50
Publication Date: 2013/10/09
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2013.09.002 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Shirin Sayyahfar
AU  - Abdollah Karimi
AU  - Alireza Fahimzad
AU  - Ahmad Reza Shamshiri
PY  - 2013
DA  - 2013/10/09
TI  - Comparison of Tuberculin Skin Test result and interferon gamma response to human PPD in BCG scar positive and negative children
JO  - Journal of Epidemiology and Global Health
SP  - 45
EP  - 50
VL  - 4
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2013.09.002
DO  - 10.1016/j.jegh.2013.09.002
ID  - Sayyahfar2013
ER  -

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