Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data

Nahid Sherbini; Ayman Iskandrani; Ayman Kharaba; Ghalilah Khalid; Mohammed Abduljawad; Hamdan AL-Jahdali

doi:10.1016/j.jegh.2016.05.002

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Volume 7, Issue 1, March 2017, Pages 29 - 36

Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data

Authors

Nahid Sherbini^a^{, *}^,drnahed@yahoo.com, Ayman Iskandrani^b^,monmonsa@hotmail.com, Ayman Kharaba^b^,a7yman@hotmail.com, Ghalilah Khalid^b^,Kghalilah@yahoo.com, Mohammed Abduljawad^b^,samamohammedhabeb@yahoo.com, Hamdan AL-Jahdali^a^,jahdalih@gmail.com

^aKing Abdulaziz Medical City – Riyadh, Department of Medicine – Pulmonary Division, King Saud University for Health Sciences, Saudi Arabia

^bKing Fahad Hospital, Internal Medicine – Al-Madinah, Saudi Arabia

^*Corresponding author. Mobile: +966 503502050.

Corresponding Author

Nahid Sherbinidrnahed@yahoo.com

Received 22 October 2015, Revised 20 April 2016, Accepted 9 May 2016, Available Online 11 June 2016.

DOI: 10.1016/j.jegh.2016.05.002 How to use a DOI?
Keywords: Characteristics; Coronavirus; Epidemiology; MERS; Saudi Arabia; Survival
Abstract: Background Middle East respiratory syndrome coronavirus (MERS-CoV), is an emerging virus respiratory infection. It has a high mortality rate and a wide spectrum of clinical features. This study describes the clinical characteristics and outcome of MERS infected patients.

Methods A retrospective study was conducted of all confirmed MERS-CoV infections from March 2014 to May 2014 at two tertiary care hospitals in Al-Madinah region (Saudi Arabia). We gathered data about demographic, clinical presentation, and factors associated with severity and mortality.

Results A total of 29 cases were identified; 20 males (69%) and nine females (31%), age 45 ± 12 years. The death rate was higher for men (52%) than for women (23%). Initial presentation was fever in 22 (75%) cases, cough in 20 (69%) cases, and shortness of breath in 20 (69%) cases. Associated comorbidities were diabetes mellitus in nine (31%) patients and chronic kidney disease (CKD) in eight (27%) patients. Duration of symptoms before hospitalization ranged from 2.9 days to 5 days. Elevated liver enzymes were present in 14 (50%) patients and impaired renal profile present in eight (27%) patients. We also describe in this study radiological patterns and factors associated with mortality.

Conclusion MERS-CoV infection transmission continues to occur as clusters in healthcare facilities. The frequency of cases and deaths is higher among men than women and among patients with comorbidities.
Copyright: © 2016 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 7 - 1
Pages: 29 - 36
Publication Date: 2016/06/11
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2016.05.002 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Nahid Sherbini
AU  - Ayman Iskandrani
AU  - Ayman Kharaba
AU  - Ghalilah Khalid
AU  - Mohammed Abduljawad
AU  - Hamdan AL-Jahdali
PY  - 2016
DA  - 2016/06/11
TI  - Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data
JO  - Journal of Epidemiology and Global Health
SP  - 29
EP  - 36
VL  - 7
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2016.05.002
DO  - 10.1016/j.jegh.2016.05.002
ID  - Sherbini2016
ER  -

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