Journal of Epidemiology and Global Health

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Volume 9, Issue 1, March 2019, Pages 56 - 61

Pediatric Multidrug-resistant Tuberculosis in Kyiv City, Ukraine

Authors
Silvia Shinpei Chiang1, 2, Yana Sheremeta3, Rachel Sophie Padilla4, Helen Elizabeth Jenkins5, Charles Robert Horsburgh6, 7, Vasyl Petrenko3, Natasha Renee Rybak4, 8, *
1Department of Pediatrics, Alpert Medical School of Brown University, Providence, RI, USA
2Center for International Health Research, Rhode Island Hospital, Providence, RI, USA
3Department of Tuberculosis and Pulmonology, Bogomolets National Medical University, Kyiv, Ukraine
4Department of Medicine, The Miriam Hospital, Providence, RI, USA
5Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
6Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
7Department of Medicine, Boston University School of Medicine, Boston, MA, USA
8Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA
*Corresponding author. Email: nrybak@lifespan.org
Corresponding Author
Natasha Renee Rybak
Received 8 July 2018, Accepted 16 October 2018, Available Online 27 March 2019.
DOI
10.2991/jegh.k.190225.002How to use a DOI?
Keywords
Multidrug-resistant tuberculosis; children; adolescent; Ukraine
Abstract

Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite the fact that these countries have the highest proportion of TB cases that are MDR. We aimed to examine pediatric MDR-TB in Ukraine. This retrospective cohort study included all children <18 years of age who started undergoing MDR-TB treatment between January 1, 2011 and July 31, 2016 at Kyiv City Pediatric TB Hospital. From each child’s clinical chart, we abstracted demographic and clinical data. Using Fisher’s exact test, we compared characteristics between children with microbiologically confirmed vs. probable (i.e., clinically diagnosed) MDR-TB. The study population included 20 children with a median age of 5 years. At diagnosis, 12 (60%) had intrathoracic lymphadenopathy as their only radiographic abnormality, and two (10%) were asymptomatic. Children with confirmed MDR-TB were more likely to be adolescents or have radiologic abnormalities in addition to intrathoracic lymphadenopathy. Median treatment duration was 20 months. Eighteen (90%) children were treated successfully. The remaining two were transferred to another facility, and their final outcomes were unknown. The excellent outcomes in this cohort are consistent with high treatment success rates for pediatric MDR-TB reported in other parts of the world.

Copyright
© 2019 Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
Journal of Epidemiology and Global Health
Volume-Issue
9 - 1
Pages
56 - 61
Publication Date
2019/03/27
ISSN (Online)
2210-6014
ISSN (Print)
2210-6006
DOI
10.2991/jegh.k.190225.002How to use a DOI?
Copyright
© 2019 Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Silvia Shinpei Chiang
AU  - Yana Sheremeta
AU  - Rachel Sophie Padilla
AU  - Helen Elizabeth Jenkins
AU  - Charles Robert Horsburgh
AU  - Vasyl Petrenko
AU  - Natasha Renee Rybak
PY  - 2019
DA  - 2019/03/27
TI  - Pediatric Multidrug-resistant Tuberculosis in Kyiv City, Ukraine
JO  - Journal of Epidemiology and Global Health
SP  - 56
EP  - 61
VL  - 9
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.2991/jegh.k.190225.002
DO  - 10.2991/jegh.k.190225.002
ID  - Chiang2019
ER  -