Clinical Hematology International

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Volume 1, Issue 3, September 2019, Pages 154 - 160

Allogeneic Stem Cell Transplantation with CD34+ Cell Selection

Authors
Elisa Roldan1, Miguel Angel Perales2, *, Pere Barba1, *
1Hematology Department, Vall d'Hebron University Hospital-Universitat Autónoma de Barcelona, Pg. Vall Hebron 119, Barcelona, Spain
2Adult BMT Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
*Corresponding authors. Ph.: +34.93.274.64.14. E-mail: pbarba@vhio.net (PB);
Ph.: 212-639-8682; Fax: 212-717-3500. E-mail: peralesm@mskcc.org (MAP)
Corresponding Authors
Miguel Angel Perales, Pere Barba
Received 19 March 2019, Accepted 4 June 2019, Available Online 1 September 2019.
DOI
10.2991/chi.d.190613.001How to use a DOI?
Keywords
Allogeneic transplant; Graft-versus-host disease; T cell depletion; CD34+ cell selection; Graft-versus-host disease-free and relapse-free survival (GRFS)
Abstract

The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients.

In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.

Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
Clinical Hematology International
Volume-Issue
1 - 3
Pages
154 - 160
Publication Date
2019/09/01
ISSN (Online)
2590-0048
DOI
10.2991/chi.d.190613.001How to use a DOI?
Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Elisa Roldan
AU  - Miguel Angel Perales
AU  - Pere Barba
PY  - 2019
DA  - 2019/09/01
TI  - Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
JO  - Clinical Hematology International
SP  - 154
EP  - 160
VL  - 1
IS  - 3
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190613.001
DO  - 10.2991/chi.d.190613.001
ID  - Roldan2019
ER  -