Artery Research

Introduction: Anti-hypertensive agents differ in their ability to slow progression of the increase in carotid artery intima-media thickness (IMT) with disease and have different effects on the lumen diameter (LD) of the carotid artery. We hypothesised that changes in flow and shear stress in the common...

Purpose: A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in...

Aim of Study: Due to absorption of carbon dioxide and elevated intraabdominal pressure, pneumoperitoneum during laparoscopic cholecystectomy has potentially harmful intraoperative cardiovascular effects. Our aim was to test the usefulness of a non-invasive method for detecting these hemodynamic parameters. Methods:...

Background The hemodynamic effects of the vasodilator β-blocker nebivolol may differ from those of a conventional agent. Wave intensity analysis can describe the energy transported by wavefronts in the arterial system in the direction of wave propagation. A non-invasive ultrasound-based technique [1]...

AIM of this study was to evaluate the clinical efficacy of long-acting nitrates, isosorbide-5-mononitrate (ISMN), in addition to ACE inhibitor on artery stiffness in patients with essential hypertension. MATERIALS AND METHODS. 40 hypertensive patients (mean age 61.3±7.4 years, 9 male, 31 female, mean...

The commonest causes of dementia are Alzheimer’s disease and vascular cognitive impairment. Although these conditions have been viewed as distinct entities, there is increasing evidence that neurodegenerative and vascular pathologies interact or overlap to cause cognitive decline, and that at least in...

Objectives: evolution of hypertensive patients during their stay in the CCU after myocardial revascularization surgery (MRS). Methods: retrospective study with 90 patients. Results: prevalence of AHT before surgery was 86.7%; 61.3% were treated with BB, 39% received ACEI, 11% calcium antagonists and...

Introduction: While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk. We assessed the acute effect of vardenafil on arterial...

Background: Vascular load is an important determinant of ventricular function. Understanding the physiologic basis of vascular load is central to the development of new strategies and drugs to treat HF. Aim: to evaluate arterial stiffness, endothelial function, clinical status at baseline and in 6 months...

It is commonly assumed that pressure and flow in the arteries are purely the result of forward and backward travelling waves. We will show that various observations of arterial behaviour are difficult to explain using this assumption. In particular we will look at what happens to arterial pressure under...

Background: Vascular B1 kinin receptor expression is upregulated in human atheroma and the presence of angiotensin-converting enzyme inhibition (ACEi), but its role in man remains unclear. We examined vasomotor and fibrinolytic responses to selective kinin receptor agonism in the human femoral circulation...

Background: The mechanisms of endogenous progenitor cell trafficking in response to tissue injury in humans are poorly understood. Methods: We based our study on a model of transient myocardial injury, provoked by the use of cardiopulmonary bypass during cardiac surgery in 39 patients. Bone marrow (BM)...

Arterial stiffness (AS) and central BP (CBP) are new «target-objects» for Antihypertensive Therapy (AT), but the possibility to correction these parameters on nonmedicament treatment is discussed. Aim: To research the possibilities of correction of AS and CBP by AT and Continuous Positive Airway Pressure...

Background: We have previously shown increased arterial stiffness using aortic pulse wave velocity (PWV) in patients with COPD. Pulmonary rehabilitation (PR) (exercise, education and nutritional advice) has respiratory and functional benefits, though effects on cardiovascular (CV) risk have not been...

Purpose: Aortic stiffness and wave reflections are determinants of left ventricular performance and independent predictors of cardiovascular risk. Though it is well recognized that regular aerobic exercise can affect arterial stiffness and wave reflections, the acute effect of intense aerobic exercise...

Objectives: To evaluate the effect of recombinant human TSH (rhTSH) on endothelial function, aortic and carotid stiffness, and wave reflection in a population living in the Chernobyl area at the time of 1986 blast, treated with thyroidectomy for thyroid cancer. Methods: 23 subjects (age 26±3 years,...

Endothelial dysfunction (ED) and carotid artery intima-media complex thickening (IMT) are regarded as predictors for the progress of atherosclerosis. The anti-oxidant properties of bilirubin and its ability to prevent oxidation of lipids of low density lipoproteins, and thus, development of vascular...

Objective: According to data of epidemiological and clinical studies, migraine with aura (MA) is associated with cardiovascular disorders, and migraine without aura (M0) is linked to carotid artery dissection. The aim of this cross-sectional study was to evaluate and compare arterial wall parameters...

Objectives: To compare the effect of Subclavian Flap Repair (SFR) versus end-to-end anastomosis (EEA) on arterial stiffness and systolic blood pressure in young children with aortic coarctation. Methods: Pulse wave velocity (PWV) was measured using a pulse volume recording technique (Vicorder, Skidmore...

It is known that reproductive hormones influence both local vascular properties and autonomic nervous reactivity. The aim of our study was to measure the small artery compliance, cutaneous LD flux response to local cooling and heart rate variability in women in the third trimester of normal pregnancy...

Objective: The aim of the study was to asses the relationship between structural (IMT- intima-media thickness) and functional (PWV - pulse wave velocity, SBP - systolic blood pressure, PP - pulse pressure) parameters of the large arterial damage and the mean blood flow velocity (CBFV) in middle cerebral...

Background: As survival in the common autosomal recessive condition Cystic Fibrosis (CF) improves, there is focus on extra-pulmonary complications. Patients with CF have increased augmentation index (AIx) at rest which is greatest in those with diabetes (CFRD). We evaluated haemodynamic response to exercise,...

Although, the cardioprotective effects of aerobic exercise are proven, not much is known about resistance exercise. Arterial wave reflection measured as augmentation index (AIx), and pulse pressure(PP) amplification are independent prognosticators of CV morbidity and mortality. However, how these parameters...