P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?

Joana Ferreira; Alexandre Carneiro; Pedro Cunha; Armando Mansilha; Isabel Vila; Cristina Cunha; Cristina Silva; Adhemar Longatto-Filho; Maria Correia-Neves; Gustavo Soutinho; Luís Meira-Machado; Amilcar Mesquita; Jorge Cotter

doi:10.2991/artres.k.201209.072

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Volume 26, Issue Supplement 1, December 2020, Pages S86 - S87

P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?

Authors

Joana Ferreira¹^{, 2}^{, 3}^{, *}, Alexandre Carneiro⁴, Pedro Cunha²^{, 3}^{, 5}^{, 6}, Armando Mansilha⁷^{, 8}, Isabel Vila²^{, 3}^{, 5}^{, 6}, Cristina Cunha²^{, 3}^{, 5}^{, 6}, Cristina Silva²^{, 3}^{, 5}^{, 6}, Adhemar Longatto-Filho²^{, 6}^{, 9}^{, 10}^{, 11}, Maria Correia-Neves²^{, 9}, Gustavo Soutinho¹², Luís Meira-Machado¹³, Amilcar Mesquita¹, Jorge Cotter²^{, 3}^{, 5}^{, 6}

¹Vascular Surgery Department- Hospital da Senhora da Oliveira

²Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho

³ICVS/3B’s-PT Government Associate Laboratory

⁴Radiology Department- ULSAM

⁵Medicine Department- Hospital da Senhora da Oliveira

⁶Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department- Hospital da Senhora da Oliveira

⁷Faculdade de Medicina da Universidade do Porto

⁸Vascular Surgery Department Hospital de São João

⁹ICVS/3B’s-PT Government Associate Laboratory

¹⁰Department of Pathology (LIM-14), University of São Paulo School of Medicine

¹¹Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos

¹²Institute of Public Health of the University of Porto (ISPUP)-University of Porto

¹³Centre of Molecular and Environmental Biology & Department of Mathematics-University of Minho

^*Corresponding author. Email: joana222@gmail.com

Corresponding Author

Joana Ferreira

Available Online 31 December 2020.

DOI

10.2991/artres.k.201209.072 How to use a DOI?

Keywords

Sarcopenia; strength; atherosclerosis

Abstract

Purpose/Background: Sarcopenia (decrease of muscle mass and function) has been linked with atherosclerosis [1]. The EWGSOP2 updated consensus, uses low muscle strength as the primary indicator of sarcopenia [2]. It is acknowledged that strength is better than mass for predicting adverse outcomes [2]. Handgrip strength (HGS) is a simple assessment to estimate overall muscular strength [3]. and is associated with cardiovascular mortality [4].

Objective: Analyze the relationship between HGS and atherosclerotic disease (carotid artery disease + lower extremity artery disease).

Methods: Prospective observation study was conducted from January to December 2019. The clinical and demographic data was recorded. Isometric HGS was measured with an adjustable handheld dynamometer (Jamar The higher value of each arm was used to classify the patient as sarcopenic or non-sarcopenic. Definition of sarcopenia: HGS <30 kgf in men and <20 kgf in women [5].

Results: 94 patients (aged 44–86 years) were analyzed: 64 sarcopenic and 30 non sarcopenic. Groups differed in the prevalence of diabetes and smoking status (Table 1). No differences were found in the carotid parameters analyzed (Table 1). There was, a difference in the prevalence of chronic limb-threatening ischemia (CLTI) in sarcopenic versus non-sarcopenic group (23.44% versus 6.67% p = 0.046). Importantly, binary logistic regression showed that diabetes (p = 0.014), and HGS (p = 0.027) have a significant effect on CLTI (Table 2).

	Sarcopenia (n = 64)	No Sarcopenia (n = 30)	p
Age (years)	69.81 ± 8.79	62.6 ± 8.61	p = 0.889
Male	47 (73.44%)	27 (90.00%)	p = 0.067
Hypertension	51 (79.69%)	21 (70.00%)	p = 0.301
Dyslipidemia	47 (73.43%)	18 (60.00%)	p = 0.189
Smoking load (UMA)	24.42 ± 33.14	37.76 ± 31.8	p = 0.748
Smoker/Ex-smoker	33 (51.56%)	24 (80.00%)	p = 0.013*
Diabetes	28 (43.75%)	7 (23.33%)	p = 0.049*
Coronary disease	11 (17.19%)	4 (13.33%)	p = 0.613
History of stroke	11 (17.19%)	3 (10.00%)	p = 0.347
Total cholesterol (mg/dL)	158.16 ± 39.82	159.6 ± 30.72	p = 0.22
LEAD	43 (67.19%)	17 (56.67%)	p = 0.275
Claudicants	28 (43.75%)	15 (50.00%)	p = 0.615
CLTI	15 (23.44%)	2 (6.67%)	p = 0.046*
ABI right	0.83 ± 0.24	0.78 ± 0.29	p = 0.287
ABI left	0.81 ± 0.28	0.77 ± 0.23	p = 0.671
Right carotid artery stenosis
50–70	4 (6.25%)	2 (6.67%)	p = 0.952
>70%	58 (90.63%)	27 (90.00%)	p = 0.702
Light carotid artery stenosis
50–70	3 (4.79%)	1 (3.33%)	p = 0.787
>70%	4 (6.25%)	2 (6.67%)	p = 0.903
Area right carotid plaque (mm²)	21.22 ± 19.81	20.01 ± 17.04	p = 0.622
Average IMT- right (mm)	0.96 ± 0.41	0.88 ± 0.24	p = 0.159
Area left carotid plaque (mm²)	21.46 ± 18.73	21.47 ± 22.06	p = 0.948
Average IMT- left (mm)	0.93 ± 0.25	0.88 ± 0.29	p = 0.861

Independent variables	Categories	β	95% CI	p
CLTI	Diabetes	1.488	1.34–14.60	0.014
CLTI	Higher HGS	−0.888	0.846–0.990	0.027

Conclusions: No relationship was found between sarcopenia (measured by HGS) and carotid atherosclerosis, differing from other authors [1,6]. In this study, sarcopenic had a higher incident of diabetes and CLTI. Sarcopenia and diabetes are reciprocally related and may share a similar pathogenetic pathway [7,8,9].

Copyright

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S86 - S87
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.072 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Joana Ferreira
AU  - Alexandre Carneiro
AU  - Pedro Cunha
AU  - Armando Mansilha
AU  - Isabel Vila
AU  - Cristina Cunha
AU  - Cristina Silva
AU  - Adhemar Longatto-Filho
AU  - Maria Correia-Neves
AU  - Gustavo Soutinho
AU  - Luís Meira-Machado
AU  - Amilcar Mesquita
AU  - Jorge Cotter
PY  - 2020
DA  - 2020/12/31
TI  - P.63 Sarcopenia and Atherosclerotic Occlusive Disease: How Much We Know and What We Need to Know About this Association?
JO  - Artery Research
SP  - S86
EP  - S87
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.072
DO  - 10.2991/artres.k.201209.072
ID  - Ferreira2020
ER  -

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