P.21 Albuminuria intensifies the relationship between urinary sodium excretion and central pulse pressure: the Wakuya study

Kaname Tagawa; Yusuke Tsuru; Katsumi Yokoi; Takanori Aonuma; Junichiro Hashimoto

doi:10.2991/artres.k.201209.034

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Volume 26, Issue Supplement 1, December 2020, Pages S43 - S43

P.21 Albuminuria intensifies the relationship between urinary sodium excretion and central pulse pressure: the Wakuya study

Authors

Kaname Tagawa¹^{, *}, Yusuke Tsuru², Katsumi Yokoi², Takanori Aonuma³, Junichiro Hashimoto¹

¹Miyagi University of Education Medical Center

²Wakuya National Health Insurance Hospital

³Wakuya Medical and Welfare Center

^*Corresponding author. Email: tagawakaname@gmail.com

Corresponding Author

Kaname Tagawa

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.034 How to use a DOI?
Keywords: Central hemodynamics; kidney; sodium
Abstract: Objectives: Central pulse pressure (cPP) is responsible for vital organ hemodynamics, [1,2] and its monitoring is important for cardiovascular disease prevention. [3] Excess sodium intake and (micro)albuminuria, a manifestation of renal microvascular damage, are also known as strong predictors of cardiovascular disease. [4,5] We sought to investigate the cross-sectional relationships among dietary sodium consumption, albuminuria and cPP in the general population.

Methods: Subjects were 933 apparently healthy adults in Wakuya town, Miyagi, Japan (mean age, 56 ± 10 years). Radial pressure waveforms were recorded with applanation tonometry to estimate mean arterial pressure (MAP), cPP, forward and backward pressure amplitudes, and augmentation index. Urinary sodium/creatinine ratio (UNaCR) and albumin/creatinine ratio (UACR) were measured in spot urine samples.

Results: Median values of UNaCR, UACR and cPP were 139 (interquartile range, 89–205) mEq/g, 5 (4–11) mg/g and 38 (33–45) mmHg, respectively. Both UACR and UNaCR were positively correlated with cPP, even after adjusted for MAP (p < 0.001). Moreover, UACR and UNaCR had a synergistic influence on increasing cPP, which was independent of age, sex, estimated glomerular filtration rate, hyperlipidemia and diabetes (interaction p < 0.05). A similar synergistic influence between UACR and UNaCR was found on the forward but not backward pressure amplitude or augmentation index. The overall results were not altered on replacement of UACR with the existence of chronic kidney disease.

Conclusions: (Micro)albuminuria strengthens the positive association between urinary sodium excretion and central pulse (and systolic forward) pressure. Excess sodium intake may magnify cardiovascular risk through widening aortic pulsatile pressure, particularly in the presence of concomitant chronic kidney disease.
Copyright: © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCES

[1]RR Townsend, JA Chirinos, A Parsa, MA Weir, SM Sozio, JP Lash, et al., Central pulse pressure in chronic kidney disease, Hypertension, Vol. 56, 2010, pp. 518-24.

[2]J Hashimoto and S Ito, Central pulse pressure and aortic stiffness determine renal hemodynamics, Hypertension, Vol. 58, 2011, pp. 839-46.

[3]C Vlachopoulos, K Aznaouridis, MF O’Rourke, ME Safar, K Baou, and C Stefanadis, Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis, Eur Heart J, Vol. 31, 2010, pp. 1865-1871.

[4]K Matsushita, M van der Velde, BC Astor, M Woodward, AS Levey, PE de Jong, et al., Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis, Lancet, Vol. 375, 2010, pp. 2073-2081.

[5]J Hashimoto, T Aikawa, and Y Imai, Large artery stiffening as a link between cerebral lacunar infarction and renal albuminuria, Am J Hypertens, Vol. 21, 2008, pp. 1304-309.

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S43 - S43
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.034 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Kaname Tagawa
AU  - Yusuke Tsuru
AU  - Katsumi Yokoi
AU  - Takanori Aonuma
AU  - Junichiro Hashimoto
PY  - 2020
DA  - 2020/12/31
TI  - P.21 Albuminuria intensifies the relationship between urinary sodium excretion and central pulse pressure: the Wakuya study
JO  - Artery Research
SP  - S43
EP  - S43
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.034
DO  - 10.2991/artres.k.201209.034
ID  - Tagawa2020
ER  -

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