Artery Research

<Previous Article In Issue
Next Article In Issue>
Volume 26, Issue Supplement 1, December 2020, Pages S57 - S57

P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring

Authors
Ekaterina Selivanova1, *, Anastasia Shvetsova1, Victoria Potekhina1, Dina Gaynullina1, Anna Borzykh2, Oxana Kiryukhina3, Vladislav Kuzmin1, Olga Tarasova1
1Lomonosov Moscow State University
2SRC RF IBMP RAS
3IITP RAS
*Corresponding author. Email: blamanche@ya.ru
Corresponding Author
Ekaterina Selivanova
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.047How to use a DOI?
Keywords
preeclampsia; hypertension; intrauterine programming
Abstract

Background: Preeclampsia is a common pregnancy disease characterized by hypertension and kidney failure. Recent studies have shown that even in the case of successful delivery, preeclampsia could induce long-term effects in the offspring. Nevertheless, the effects of preeclampsia on the cardiovascular system of the offspring are poorly studied.

Methods: We induced preeclampsia in pregnant rats by L-NAME (nitric oxide synthase inhibitor) supplementation (250 mg/l in drinking water from gestation day 10 to delivery, daily dose 39 mg/kg). The model was verified by the dam’s blood pressure (BP) elevation (tail-cuff) and creatinine clearance reduction (metabolic cages) compared to control dams. Male offspring 16-18-day old were used for BP recording (catheter technique under urethane anesthesia); their isolated arteries were studied by wire myography. Adrenergic nerve plexus was visualized by glyoxylic acid staining.

Results: Offspring of dams with preeclampsia had reduced body weight compared to control. They also demonstrated decreased BP (43.3 ± 1.9 vs 50.5 ± 1.4 mmHg) and diminished response to the ganglionic blocker chlorizondamine (2.5 mg/kg); heart rate didn’t differ between the groups. The density of the sympathetic innervation of the right atrium and the saphenous artery was reduced in the preeclampsia offspring. Saphenous arteries from preeclampsia offspring had smaller diameter (276 ± 5 vs. 296 ± 7 micron) and maximal contraction force (9.4 ± 0.4 vs. 10.6 ± 0.4 mN) compared to control.

Conclusions: Preeclampsia is followed by the delay in sympathetic nervous system development in the offspring, which is accompanied by structural and functional alterations in the cardiovascular system.

The research was supported by Russian Science Foundation (Grant N 19-15-00210).

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S57 - S57
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.047How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Ekaterina Selivanova
AU  - Anastasia Shvetsova
AU  - Victoria Potekhina
AU  - Dina Gaynullina
AU  - Anna Borzykh
AU  - Oxana Kiryukhina
AU  - Vladislav Kuzmin
AU  - Olga Tarasova
PY  - 2020
DA  - 2020/12/31
TI  - P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring
JO  - Artery Research
SP  - S57
EP  - S57
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.047
DO  - 10.2991/artres.k.201209.047
ID  - Selivanova2020
ER  -