Artery Research

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Volume 26, Issue Supplement 1, December 2020, Pages S40 - S40

P.18 Carotid Stiffness Parameters and Cerebral Blood Flow Pulsatility in Young Healthy Individuals across Races

Authors
Jie Liu1, *, Michelle E. Favre1, Stephanie G. Iring1, Allan Knox2, Jorge M. Serrador1
1Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ
2California Lutheran University, Thousand Oaks, CA
*Corresponding author. Email: jieliu.dr@rutgers.edu
Corresponding Author
Jie Liu
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.031How to use a DOI?
Keywords
Carotid compliance; transcranial; ultrasound
Abstract

Background: Higher cerebral blood flow (CBF) pulsatility was found to be associated with severer brain white matter lesions in the elderly [1]. It was hypothesized that the central/elastic arterial stiffness/compliance may directly affect CBF pulsatility. However, it is still unclear which carotid stiffness parameters may better reflect this impact, and whether race and sex differences are present.

Methods: To study the correlations among those parameters with comparisons between different races and sexes, we enrolled 35 young healthy subjects (19 females), aged 29 ± 5 (18∼40) years, with three races of comparable age and sex ratio, i.e. White (n = 16), Black (n = 7), and Asian (n = 12). All subjects were in resting seated position, with continuous transcranial Doppler recording of CBF velocity at middle cerebral artery (MCA), simultaneous 1-min ultrasound echo-tracking on bilateral common carotid arteries, and multiple measurements of brachial blood pressure (BP).

Results: All derived parameters [2], including MCA pulsatility index (PI), showed no significant racial differences but with significantly (p < 0.05) higher carotid stiffness index (β), Peterson’s pressure modulus (Ep), BP pulsatility index (mostly driven by higher systolic BP but similar diastolic BP), and lower arterial compliance (AC, p = 0.07) in males than in females. Only AC (but not β and Ep) showed a significant correlation with PI (r = 0.49, p = 0.004) even after controlling for BP pulsatility index, which negatively correlated with AC (ρ = −0.35, p = 0.038).

Conclusions: Higher carotid AC (i.e. decreased stiffness) seems to enhance CBF pulsatility in young healthy populations, which might differ from the elderly.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S40 - S40
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.031How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Jie Liu
AU  - Michelle E. Favre
AU  - Stephanie G. Iring
AU  - Allan Knox
AU  - Jorge M. Serrador
PY  - 2020
DA  - 2020/12/31
TI  - P.18 Carotid Stiffness Parameters and Cerebral Blood Flow Pulsatility in Young Healthy Individuals across Races
JO  - Artery Research
SP  - S40
EP  - S40
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.031
DO  - 10.2991/artres.k.201209.031
ID  - Liu2020
ER  -