YI 1.8 A Computational Model-Based Study on the Effect of Abdominal Aortic Aneurysm on Pulse Wave Morphology

Tianqi Wang; Jordi Alastruey; Fuyou Liang

doi:10.2991/artres.k.201209.008

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Volume 26, Issue Supplement 1, December 2020, Pages S10 - S11

YI 1.8 A Computational Model-Based Study on the Effect of Abdominal Aortic Aneurysm on Pulse Wave Morphology

Authors

Tianqi Wang¹^{, 2}^{, *}, Jordi Alastruey¹, Fuyou Liang²

¹Department of Biomedical Engineering, King’s College London

²School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University

^*Corresponding author. Email: wangtianqi@sjtu.edu.cn

Corresponding Author

Tianqi Wang

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.008 How to use a DOI?
Keywords: Aneurysm; pulse wave; modelling
Abstract: Background: Abdominal aortic aneurysm (AAA) is usually asymptomatic and has an extremely high mortality if rupture occurs. Therefore, early detection and intervention are important. However, AAA is most often detected as an accidental finding during clinical imaging for other purposes [1]. Considering that AAA has a systemic impact on the biophysical properties of the cardiovascular system, pulse-wave-based diagnosis of AAA may be a potential approach for effective detection. There have been only a few studies of pulse wave propagation with AAA by using computational modelling or hydraulic simulators [2]. This study aims to provide some basic insights for pulse-wave-based diagnosis of AAA using computational modelling.

Methods: We simulated blood flow in the larger systemic arteries using the 65-year-old baseline model from the pulse wave database in Charlton et al. [3] (see Figure, left). The influence on pulse waveforms of AAA morphology (including shape, maximum diameter and length) was simulated by adjusting the geometry of the abdominal aorta IV. In addition, the influence of the local AAA stiffness and global arterial stiffness (represented by carotid-femoral pulse wave velocity) was investigated by varying the relevant model parameters.

Results: Results show that maximum diameter is the dominant morphological factor in reshaping the pulse waveform, introducing considerable changes in pulse wave indices. Moreover, both local and global arterial stiffness have a considerable impact on wave morphology in the presence of AAA (Figure, right).

Conclusion: AAA produces considerable changes in pulse wave morphology that could be used for AAA detection by using pulse wave analysis.
Copyright: © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCES

[1]N Sakalihasan, R Limet, and OD Defawe, Abdominal aortic aneurysm, Lancet, Vol. 365, 2005, pp. 1577-89.

[2]A Swillens, L Lanoye, J De Backer, N Stergiopulos, PR Verdonck, F Vermassen, et al., Effect of an abdominal aortic aneurysm on wave reflection in the aorta, IEEE Transactions on Biomedical Engineering, Vol. 55, 2008, pp. 1602-11.

[3]PH Charlton, JM Harana, S Vennin, Y Li, P Chowienczyk, and J Alastruey, Modeling arterial pulse waves in healthy aging: a database for in silico evaluation of haemodynamics and pulse wave indexes, Am J Physiol Heart Circ Physiol, Vol. 317, 2019, pp. H1062-H85.

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S10 - S11
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.008 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Tianqi Wang
AU  - Jordi Alastruey
AU  - Fuyou Liang
PY  - 2020
DA  - 2020/12/31
TI  - YI 1.8 A Computational Model-Based Study on the Effect of Abdominal Aortic Aneurysm on Pulse Wave Morphology
JO  - Artery Research
SP  - S10
EP  - S11
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.008
DO  - 10.2991/artres.k.201209.008
ID  - Wang2020
ER  -

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