4.3 CAROTID HEMODYNAMICS DURING SYMPATHETIC NERVOUS SYSTEM STIMULATION VIA HANDGRIP AND COLD PRESSURE TESTING IN YOUNG HEALTHY SUBJECTS

DOI

10.1016/j.artres.2013.10.021How to use a DOI?

Abstract

Introduction. Assessing arterial properties and hemodynamics in response to a physiological perturbation might provide additional information on an individual’s “vascular health”. The aim of this study was to assess the feasibility of measuring changes in carotid stiffness and hemodynamics in response to sympathetic nervous system stressors (Hand Grip Test (HGT) or Cold Pressor Test (CPT)).

Methods. A non-invasive protocol, consisting of two HGT (30% (HGT1) and 40% (HGT2) of maximal voluntary contraction) and CPT, was performed in 12 young healthy volunteers (6 males/6 females). Measurements included continuous finger blood pressure recordings (NexFin; non-dominant hand) and ultrasound measurement of common carotid diameter distension and flow velocity at discrete moments in time during the protocol (GE Vivid 7 system). Carotid distensibility (ÄD/D), local wave speed using the waterhammer equation (PWV_WH) and reflection magnitude (RM; ratio of backward to forward diameter wave) were derived from the data.

Results. Consistent with the overall increase in blood pressure, carotid diameter increased while ÄD/D decreased. PWV_WH and RM showed an increase during both HGT and a decrease during CPT (see Figure).

Conclusion. It is feasible to monitor the carotid hemodynamic response to a sympathetic nervous system stimulus. In this young, healthy population, the net result of the increased diameter and decreased distensibility on local PWV_WH was similar for all tests (increase) and on the magnitude of reflections was different for HGT (increase) and CPT (decrease).

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TY  - JOUR
AU  - F.J. Londono
AU  - T.S. Klopmeijer
AU  - D. Georgakopoulos
AU  - E.G. Lovett
AU  - P. Segers
PY  - 2013
DA  - 2013/11/11
TI  - 4.3 CAROTID HEMODYNAMICS DURING SYMPATHETIC NERVOUS SYSTEM STIMULATION VIA HANDGRIP AND COLD PRESSURE TESTING IN YOUNG HEALTHY SUBJECTS
JO  - Artery Research
SP  - 167
EP  - 167
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.021
DO  - 10.1016/j.artres.2013.10.021
ID  - Londono2013
ER  -