5.2 CENTRAL PULSE PRESSURE: A POSSIBLE ROBUST MARKER OF THE CARDIAC HEMODYNAMIC LOAD

DOI

10.1016/j.artres.2013.10.025How to use a DOI?

Abstract

Background. No prospective study has examined whether markers of the central hemodynamics, e.g., central pulse pressure, might be a more robust marker of change in the cardiac hemodynamic load, estimated by the change during the study period of the serum levels of N-terminal fragment B-type natriuretic peptide (NT-proBNP), as compared to markers of the arterial stiffness or brachial blood pressure variables in subjects with preserved cardiac function.

Methods. The brachial-ankle pulse wave velocity, radial augmentation index (rAI), second peak of the radial pressure waveform, systolic and pulse pressure of the second peak of the radial pressure waveform (SP2 and PP2) and serum NT-proBNP level were measured at the start (first examination) and at the end (second examination) of this 3-year study in middle-aged healthy Japanese men (n = 1851).

Results. A stepwise multivariate linear regression analysis demonstrated that only PP2, among the parameters related to arterial stiffness and central hemodynamics and also brachial blood pressure variables, was significantly associated with the serum NT-pro BNP levels in the subjects. Furthermore, only the changes of the PP2 during the study period, among the parameters related to arterial stiffness and central hemodynamics, were significantly correlated with those of the serum NT-pro BNP levels during the study period (beta = 0.131, p < 0.001).

Conclusion. Central pulse pressure, as reflected by PP2, may be a robust marker of the cardiac hemodynamic load and reflect changes in the cardiac hemodynamic load even in persons with preserved cardiac function.

Keywords. Natriuretic peptides, Central blood pressure, Cardiac hemodynamic load

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - M. Odaira
AU  - H. Tomiyama
AU  - A. Yamashina
PY  - 2013
DA  - 2013/11/11
TI  - 5.2 CENTRAL PULSE PRESSURE: A POSSIBLE ROBUST MARKER OF THE CARDIAC HEMODYNAMIC LOAD
JO  - Artery Research
SP  - 168
EP  - 168
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.025
DO  - 10.1016/j.artres.2013.10.025
ID  - Odaira2013
ER  -