Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 166 - 166

3.4 VASCULAR AGING MAY CONTRIBUTE TO TELOMERE LENGTH IN PATIENTS WITH T2DM

Authors
E.N. Dudinskaya1, N.V. Brailova1, I.D. Strazhesko1, O.Y. Isaikina1, M.S. Pokrovskaya1, O.N. Tkacheva1, S.A. Boytsov1, M.V. Shestakova2
1National Research Centre for Preventive Medicine, Moscow, Russian Federation
2National Research Center for Endocrinology, Moscow, Russian Federation
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.017How to use a DOI?
Abstract

It is known that telomere length (TL) shortening is a marker of cell aging, which accelerated and progresses in type 2 diabetes mellitus (T2DM), despite the patient’s age, leading to the vascular aging.

The aim of the study was to compare the vascular and cellular aging in patients with and without T2DM.

Methods. TL was assessed by quantitative polymerase chain reaction (PCR) in 35 patients with T2DM (mean age 61±2,6 years) and in 43 healthy patients in mean age of 51±1,8 years. IMT and PP were determined by ultrasonography in both left and right carotid arteries. AS was appreciated by aortic pulse wave velocity (PWV) measuring by SphygmoCor (AtCor Medical).

Results. All patients were divided into 2 groups by TL – “long” and “short” telomeres. Comparison of vascular aging parameters was carried out in groups with and without T2DM. Results are summarized in Tables 1 and 2.

T2DM+ (n = 15) T2DM− (n = 23) p
TL 10.2 ± 0.05 10.4 ± 0.1 0.06
PWV (m/s) 10.58 ± 0.1 10.5 ± 0.5 0.913
IMT (mm) 0.904 ± 0.09 0.77 ± 0.03 0.1227
PP (number) 0.886 ± 0.4 0.782 ± 0.2 0.979
Table 1

Comparison in patients with “long” TL.

T2DM+ (n = 20) T2DM− (n = 20) p
TL 9.24 ± 0.1 9.28 ± 0.06 0.735
PWV (m/s) 15.08 ± 1.3 10.7 ± 0.5 0.0151
IMT (mm) 0.87 ± 0,1 0.78 ± 0.1 0.1814
PP (number) 1.125 ± 0.29 0.789 ± 0.22 0.04
Table 2

Comparison in patients with “short” TL.

Conclusion: in patients with short TL and T2DM the severity of vascular disorders is higher than in healthy people. In contrast, in patients with long TL with T2DM there are no significant differences in the vascular structure as compared with healthy individuals.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
166 - 166
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.017How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - E.N. Dudinskaya
AU  - N.V. Brailova
AU  - I.D. Strazhesko
AU  - O.Y. Isaikina
AU  - M.S. Pokrovskaya
AU  - O.N. Tkacheva
AU  - S.A. Boytsov
AU  - M.V. Shestakova
PY  - 2013
DA  - 2013/11/11
TI  - 3.4 VASCULAR AGING MAY CONTRIBUTE TO TELOMERE LENGTH IN PATIENTS WITH T2DM
JO  - Artery Research
SP  - 166
EP  - 166
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.017
DO  - 10.1016/j.artres.2013.10.017
ID  - Dudinskaya2013
ER  -