P5.31 CENTRAL PRESSURES ARE HIGHER IN PATIENTS WITH TRANSIENT ISCHAEMIC ATTACK (TIA) THAN HEALTHY ADULTS

S.R.U. Patel; E. Bunting; E. Bodenham; S.A. Hopkins; E. Ormerod; J. Timeyin; K. Ali; C. Rajkumar

doi:10.1016/j.artres.2013.10.179

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Volume 7, Issue 3-4, September 2013, Pages 152 - 152

P5.31 CENTRAL PRESSURES ARE HIGHER IN PATIENTS WITH TRANSIENT ISCHAEMIC ATTACK (TIA) THAN HEALTHY ADULTS

Authors

S.R.U. Patel¹, E. Bunting², E. Bodenham², S.A. Hopkins², E. Ormerod², J. Timeyin², K. Ali¹, C. Rajkumar¹

¹Brighton and Sussex Medical School, Brighton, United Kingdom

²Brighton and Sussex University Hospitals Trust, Brighton, United Kingdom

Available Online 11 November 2013.

DOI

10.1016/j.artres.2013.10.179 How to use a DOI?

Abstract

Introduction: The increased risk of stroke following a Transient Ischaemic Attack (TIA) is well established. Central aortic pressure, a marker of arterial stiffness, is emerging as a predictor of cardiovascular events including stroke. Additionally brachial Blood Pressure (BP) measurements may not accurately reflect the haemodynamic status of an individual, as systolic BP is amplified peripherally. The association and interplay of central aortic pressure and brachial BP parameters in TIA patients have not previously been explored.

Methods: Twenty-six participants with a mean age of 70 years (SD±10.1) and a confirmed diagnosis of TIA were recruited from Brighton and Sussex University Hospitals Trust. Central aortic BP and brachial BP were measured using Arteriograph^®. Carotid-femoral pulse wave velocity (C-F PWV) and carotid-radial pulse wave velocity (C-R PWV) were measured using Complior^®.

Results: Twenty participants had complete BP recordings. Central aortic BP was higher than peripheral BP (mean difference= 2 mmHg). Healthy patients are expected to have a central BP 10–15mmHg lower than peripheral BP.^[1,2] C-F PWV was found to be higher in TIA participants compared to published normal values (C-F 10.9 m/s).^[3]

Measurement	Mean ± SD	Range	n
Peripheral BP (mmHg)	128 ±14.7	102–163	20
Central BP (mmHg)	130 ±19.3	97–171	20
C-F PWV (m/s)	11.5 ±3.18	7.2–20.6	22
C-R PWV (m/s)	10.8 ±1.26	8.3–13.7	22

Conclusions: In this TIA cohort, there was a tendency towards an increase in central BP and aortic stiffness in comparison to published normal values.

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References

1.CM McEniery et al., Hypertension, Vol. 51, No. 6, Jun 2008, pp. 1476-82.

2.B Williams et al., Circulation, Vol. 119, No. 1, 6 Jan 2009, pp. 53-61.

3.F Mattace-Raso et al., Eur Heart J, Vol. 31, No. 19, Oct 2010, pp. 2338-50.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 152 - 152
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.179 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - S.R.U. Patel
AU  - E. Bunting
AU  - E. Bodenham
AU  - S.A. Hopkins
AU  - E. Ormerod
AU  - J. Timeyin
AU  - K. Ali
AU  - C. Rajkumar
PY  - 2013
DA  - 2013/11/11
TI  - P5.31 CENTRAL PRESSURES ARE HIGHER IN PATIENTS WITH TRANSIENT ISCHAEMIC ATTACK (TIA) THAN HEALTHY ADULTS
JO  - Artery Research
SP  - 152
EP  - 152
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.179
DO  - 10.1016/j.artres.2013.10.179
ID  - Patel2013
ER  -

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