P5.10 MAJOR BRACHIAL-TO-RADIAL-SYSTOLIC-BLOOD-PRESSURE-AMPLIFICATION OCCURS IN HEALTHY PEOPLE AND IS SIGNIFICANTLY INCREASED WITH AGE

DOI

10.1016/j.artres.2013.10.159How to use a DOI?

Abstract

Objectives: The reference standard for non-invasive central blood pressure (BP) measurement is radial tonometry calibrated using brachial BP. Brachial-to-radial-systolic-BP-amplification (Bra-Rad-SBP_Amp) may introduce error into central BP measurement but the magnitude of Bra-Rad-SBP_Amp in healthy people is uncertain. This study aimed to determine the magnitude of Bra-Rad-SBP_Amp as well as effects of ageing.

Methods: Forty healthy younger (28±5 years; 50% male) and 20 older (60±8 years; 50% male) participants underwent brachial and radial artery ultrasound measurement to identify SBP (1^st Korotkoff sound) from the 1^st Doppler flow inflection point during BP cuff deflation. Regional and local haemodynamics were recorded by ultrasound and tonometry. Bra-Rad-SBP_Amp was calculated by radial minus brachial SBP.

Results: Radial SBP was significantly higher than brachial SBP in both younger (118±12mmHg versus 110±10mmHg; p<0.001) and older (135±12mmHg versus 121±11mmHg; p<0.001) participants. However, the magnitude of Bra-Rad-SBP_Amp was higher in older age (14±7mmHg versus 8±7mmHg; p=0.004), and this was independent of heart rate, mean arterial pressure and sex. A higher proportion of older participants had major (>15mmHg) Bra-Rad-SBP_Amp (45% versus 12.5%; p=0.028). Recalibration of radial waveforms using radial versus brachial SBP resulted in higher central SBP in both younger (p<0.001) and older (p<0.001) age groups (p<0.001 between groups). Brachial artery stiffness was related to Bra-Rad-SBP_Amp in females only.

Conclusions: Major Bra-Rad-SBP_Amp occurs in healthy people and is significantly increased with age. These findings have implications for correct central BP estimation using radial tonometry and brachial BP calibration, whereby greater underestimation of central SBP is likely with advancing age.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - D.S. Picone
AU  - R.E.D. Climie
AU  - K.D.K. Ahuja
AU  - M.A. Keske
AU  - J.E. Sharman
PY  - 2013
DA  - 2013/11/11
TI  - P5.10 MAJOR BRACHIAL-TO-RADIAL-SYSTOLIC-BLOOD-PRESSURE-AMPLIFICATION OCCURS IN HEALTHY PEOPLE AND IS SIGNIFICANTLY INCREASED WITH AGE
JO  - Artery Research
SP  - 146
EP  - 146
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.159
DO  - 10.1016/j.artres.2013.10.159
ID  - Picone2013
ER  -