P4.26 ASSOCIATIONS BETWEEN FGF23-LEVEL AND ARTERIAL DISTENSIBILITY IN CHRONIC KIDNEY DISEASE

O. Cseprekal; Németh Zs; A. Marton; E. Vámos; J. Nemcsik; J. Egresits; T. El Hajd Othmane; B. Fekete; Deák Gy; I. Kiss; A. Tislér

doi:10.1016/j.artres.2013.10.144

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 7, Issue 3-4, September 2013, Pages 142 - 143

P4.26 ASSOCIATIONS BETWEEN FGF23-LEVEL AND ARTERIAL DISTENSIBILITY IN CHRONIC KIDNEY DISEASE

Authors

O. Cseprekal¹, Németh Zs³, A. Marton³, E. Vámos¹, J. Nemcsik⁴, J. Egresits¹, T. El Hajd Othmane¹, B. Fekete¹, Deák Gy³, I. Kiss², A. Tislér¹

¹Ist Department of Internal Medicine, Semmelweis University, Budapest, Hungary

²St Imre Teaching Hospital, Division of Nephrology, Budapest, Hungary

³Uzsoki Hospital, Division of Nephrology, Budapest, Hungary

⁴Department of Family Medicine, Semmelweis University, Budapest, Hungary

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.144 How to use a DOI?
Abstract: Vascular calcification and hemodynamical abnormalities lead to reduced arterial elasticity in end stage renal disease. Fibroblast growth factor-23 (FGF23) predicts cardiovascular mortality in advance stages of renal failure possibly indicating more advanced vascular calcification. The relation of FGF23 to arterial stiffness in chronic kidney disease is currently under investigations.

The aim of our cross sectional study was to assess the potential associations between FGF23 and arterial distensibility.

FGF23 (ELISA), pulse wave velocity (PWV), augmentation index (AI) and central pulse pressure (CPP) (PulsePen), were measured in patients with different stages of renal insufficiency (n=103, 64.8±13.3 years, 50 males, eGFR 40±21 mL/min/1.73m²). Univariate and multiple linear regression models were used for the statistical analysis.

According to our results, logFGF23 showed significant relation with serum phosphate, PTH levels and renal function. There were no significant correlations between FGF23 and PWV or CPP. AI, however, correlated negatively with logFGF23 (r= −0.24, p<0.05). By multiple regressions, serum phosphate, logFGF23, systolic blood pressure and heart rate proved to be the individual predictors of AI. (R²=0.31, β=0.31, −0.33, 0.21, −0.27, p<0.05). In the subgroup of patients with <45 mL/min/1.73m² eGFR, serum phosphate and logFGF23 remained the significant predictors (R² 0.21, β=0.31, −0.39, p<0.05)

FGF23 may be a determinant of peripheral arterial elasticity independently of serum phosphate level especially in advanced stages of chronic kidney disease.

(Supported by the Hungarian Kidney Foundation and the Hungarian Society of Hypertension)
Open Access: This is an open access article distributed under the CC BY-NC license.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 142 - 143
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.144 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - O. Cseprekal
AU  - Németh Zs
AU  - A. Marton
AU  - E. Vámos
AU  - J. Nemcsik
AU  - J. Egresits
AU  - T. El Hajd Othmane
AU  - B. Fekete
AU  - Deák Gy
AU  - I. Kiss
AU  - A. Tislér
PY  - 2013
DA  - 2013/11/11
TI  - P4.26 ASSOCIATIONS BETWEEN FGF23-LEVEL AND ARTERIAL DISTENSIBILITY IN CHRONIC KIDNEY DISEASE
JO  - Artery Research
SP  - 142
EP  - 143
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.144
DO  - 10.1016/j.artres.2013.10.144
ID  - Cseprekal2013
ER  -

download .riscopy to clipboard