P4.28 GLYCAEMIC HOMEOSTASIS, ARTERIAL STIFFNESS AND DIASTOLIC FUNCTION IN HEALTHY SUBJECTS

DOI

10.1016/j.artres.2013.10.146How to use a DOI?

Abstract

Objectives: To examine the impact of glycaemic homeostasis on arterial stiffness and cardiac diastolic function in healthy subjects.

Methods: Subjects (100 male & 115 female) were normotensive and normolipidaemic and had normal oral glucose tolerance test responses. Carotid-femoral arterial stiffness (PWV) and atherosclerotic risk (carotid intima media thickness; CIMT) were measured. Early/late mitral valve filling velocity (MV E/A) and isovolumetric relaxation time (IVRT) was used to assess diastolic function. Glycosylated haemoglobin (HbA_1c) was used to determine long-term glycaemic homeostasis. Anthropometrical measurements such as height, body mass and waist circumference were also measured.

Results: Spearman’s correlation identified significant association between HbA_1c and age (r=0.40, P<0.0001), waist height ratio (r=0.18, P<0.01), PWV (r=0.26, P<0.001), CIMT (r=0.18, P<0.05), MV E/A (r=−0.37, P<0.0001) and IVRT (r=0.28, P<0.01). In multiple regression analysis’s age remained the only independent predictor of PWV, CIMT, MV E/A and IVRT.

Conclusion: Despite being clinically healthy, HbA_1c is associated with greater arterial stiffness and poor diastolic function.

Open Access

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TY  - JOUR
AU  - O. Mac Ananey
AU  - V. Maher
PY  - 2013
DA  - 2013/11/11
TI  - P4.28 GLYCAEMIC HOMEOSTASIS, ARTERIAL STIFFNESS AND DIASTOLIC FUNCTION IN HEALTHY SUBJECTS
JO  - Artery Research
SP  - 143
EP  - 143
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.146
DO  - 10.1016/j.artres.2013.10.146
ID  - MacAnaney2013
ER  -