P4.29 COMPARATIVE EFFECTS OF ANTIHYPERTENSIVE DRUGS ON OXIDATIVE STRESS AND INFLAMMATION

M. Serg; M. Zilmer; M. Zagura; J. Kals; J. Eha; K. Zilmer; T. Kullisaar; C.M. McEniery; I.B. Wilkinson; P. Kampus

doi:10.1016/j.artres.2013.10.147

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Volume 7, Issue 3-4, September 2013, Pages 143 - 143

P4.29 COMPARATIVE EFFECTS OF ANTIHYPERTENSIVE DRUGS ON OXIDATIVE STRESS AND INFLAMMATION

Authors

M. Serg¹, M. Zilmer², M. Zagura², J. Kals²^{, 3}, J. Eha¹^{, 4}, K. Zilmer², T. Kullisaar², C.M. McEniery⁵, I.B. Wilkinson⁵, P. Kampus¹^{, 2}

¹Department of Cardiology, University of Tartu, Tartu, Estonia

²Institute of Biomedicine and Translational Medicine, Department of Biochemistry, University of Tartu, Tartu, Estonia

³Department of Vascular Surgery, Tartu University Hospital, Tartu, Estonia

⁴Heart Clinic, Tartu University Hospital, Tartu, Estonia

⁵Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.147 How to use a DOI?
Abstract: Objective: Oxidative stress and vascular inflammation are increased in hypertension. These factors may contribute to target organ damage and increased cardiovascular risk in these patients. We studied the effect of four classes of antihypertensive drugs on oxidative stress and inflammatory markers in patients with essential hypertension.

Design and method: In this double-blind placebo-controlled crossover study we randomized 41 treatment-naïve hypertensive patients to receive doxazosin 4 mg, candesartan 16 mg, bisoprolol 5 mg, isosorbide mononitrate 50 mg, and placebo daily for 6 weeks. Brachial blood pressure (BP), plasma high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), asymmetric dimethylarginine (ADMA), oxidized LDL (oxLDL), soluble intercellular adhesion molecule-1 (sICAM-1), oxLDL antibodies (OLAB), and urine 8-isoprostanes were measured after each treatment period.

Results: All drugs reduced systolic, diastolic, and mean arterial pressure (p<0.001) with candesartan having the greatest effect. None of the drugs reduced inflammatory or oxidative stress markers compared to placebo. There were significant differences in between-drug analysis. Doxazosin reduced OLAB and oxLDL levels the most (p<0.05). With bisoprolol there was a trend for hsCRP and ADMA level increase compared to other drugs (p<0.01). There were no differences regarding drug effects on sICAM-1, IL-6, or 8-isoprostane levels. Changes in oxLDL and to lesser degree hsCRP and sICAM-1 levels correlated with change in BP with study drugs.

Conclusions: In our study an alpha-blocker seemed to have the most favorable effect on oxidative stress and inflammatory markers while a beta-blocker had least effect. These effects are partially dependent on the BP-lowering effects of the drugs.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 143 - 143
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.147 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - M. Serg
AU  - M. Zilmer
AU  - M. Zagura
AU  - J. Kals
AU  - J. Eha
AU  - K. Zilmer
AU  - T. Kullisaar
AU  - C.M. McEniery
AU  - I.B. Wilkinson
AU  - P. Kampus
PY  - 2013
DA  - 2013/11/11
TI  - P4.29 COMPARATIVE EFFECTS OF ANTIHYPERTENSIVE DRUGS ON OXIDATIVE STRESS AND INFLAMMATION
JO  - Artery Research
SP  - 143
EP  - 143
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.147
DO  - 10.1016/j.artres.2013.10.147
ID  - Serg2013
ER  -

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