Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 135 - 135

P4.01 PLASMA FIBULIN-1 IS INCREASED IN PATIENTS WITH ABDOMINAL AORTIC ANEURYSM BUT NOT PERIPHERAL ATHEROSCLEROTIC DISEASE

Authors
M.L. Hansen1, 4, M.D. Thomsen2, J.S. Lindholt2, 3, 4, L.M. Rasmussen1, 4
1Department of Clinical Biochemistry and Pharmacology,Odense University Hospital, Odense, Denmark
2Cardiovascular Research Unit, Viborg Hospital, Viborg, Denmark
3Department of Cardiovascular- and Thoracic Surgery, Odense University Hospital, Odense, Denmark
4Centre for Individualized Medicine In Arterial Diseases (CIMA), Odense University Hospital, Odense, Denmark
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.120How to use a DOI?
Abstract

Objectives: Fibulin-1 is an extracellular matrix protein that is increased in the arterial wall in diabetes. It is also present in plasma, where it is positively related to blood pressure and predicts mortality. In addition, plasma levels are associated with heart stiffness indices. The aim of this study was to evaluate the relation between plasma fibulin-1 and vascular diseases such as aortic abdominal aneurysm (AAA) and peripheral atherosclerotic disease (PAD).

Methods: Plasma levels of fibulin-1 were measured by ELISA in patients from an ongoing population-based screening trial for AAA, PAD and hypertension in men aged 65–74 years. Samples were obtained consecutively from 477 patients with AAA, 120 patients with PAD and AAA and 197 age-matched controls. AAA is defined as having a maximal aortic diameter > 30 mm and PAD as an ankle-brachial index (ABI) < 0.90.

Results: Plasma fibulin-1 in patients with AAA (86.2 μg/ml ± 1.01 μg/ml, mean±SEM) and controls (81.6 μg/ml. SEM ± 1.01 μg/ml) were significantly different (p=0.004), OR of 5.62 (95% C.I.: 2.29–13.79, p<0.000). In patients with additional PAD no differences in relation to controls was recognized. Fibulin-1 correlated positively to infra renal aortic size (R=0.125, p=0.001), age (R=0.174, p=0.000) and body mass index (R=0.132, p=0.001) but not to low ABI, blood pressure or AAA growth-rate. There was no difference in age between groups.

Conclusion: Plasma fibulin-1 was significantly higher in patients with AAA, but not in patients with additional PAD, which may be explained by an increase in extracellular matrix turnover related to AAA.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
135 - 135
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.120How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M.L. Hansen
AU  - M.D. Thomsen
AU  - J.S. Lindholt
AU  - L.M. Rasmussen
PY  - 2013
DA  - 2013/11/11
TI  - P4.01 PLASMA FIBULIN-1 IS INCREASED IN PATIENTS WITH ABDOMINAL AORTIC ANEURYSM BUT NOT PERIPHERAL ATHEROSCLEROTIC DISEASE
JO  - Artery Research
SP  - 135
EP  - 135
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.120
DO  - 10.1016/j.artres.2013.10.120
ID  - Hansen2013
ER  -