P3.28 CENTRAL VS. PERIPHERAL AND STEADY VS. PULSATILE BLOOD PRESSURE COMPONENTS AS DETERMINANTS OF RETINAL MICRO-VESSEL DIAMETERS

DOI

10.1016/j.artres.2013.10.115How to use a DOI?

Abstract

Objective: We assessed association of retinal micro-vessel diameter with central and peripheral BP.

Methods: We post-processed retinal photographs taken in 514 subjects randomly selected from a Flemish population (mean age, 50.6 years; 50.8% women), using IVAN software to generate retinal arteriolar (CRAE) and venular (CRVE) equivalents. We measured peripheral and central BP by mercury sphygmomanometry and tonometry at the carotid artery (SphygmoCor software), respectively. We applied stepwise regression, considering as covariables in addition to BP sex, age, body mass index, smoking, drinking, antihypertensive drug treatment, and serum cholesterol.

Results: CRAE and CRVE averaged 153μm and 219μm. Effect sizes (ìm) for CRAE for 1–SD increase in peripheral vs. central BP were –3.77 vs. –3.52 systolic, –3.16 vs. –3.13 diastolic, –3.84 vs. –3.64 for mean BP, and –2.07 vs. –1.83 for pulse pressure (P≤0.006). Models that included two BP components demonstrated that CRAE decreased (P≤0.035) with systolic (peripheral vs. central, –2.87 vs. –2.40) and diastolic (–1.58 vs. –1.80) BP. CRAE decreased with mean BP (–3.53 vs. –3.53; P<0.0001), but not with pulse pressure (P≥0.19). CRVE was not related to any peripheral or central BP component (P≥0.062). The variance inflation factor in these models was <2.0. The multivariable-adjusted slopes of CRAE on BP components were similar for centrally and peripherally measured BP (p≥0.28).

Conclusion: Higher systolic and mean BP is associated with smaller CRAE, irrespective of whether BP is measured centrally or peripherally. Central BP does not refine the inverse association of CRAE and CRVE with peripheral BP.

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TY  - JOUR
AU  - Y.-M. Gu
AU  - Y.-P. Liu
AU  - T. Kuznetsova
AU  - F.-F. Wei
AU  - H. Struijker-Boudier
AU  - J.A. Staessen
PY  - 2013
DA  - 2013/11/11
TI  - P3.28 CENTRAL VS. PERIPHERAL AND STEADY VS. PULSATILE BLOOD PRESSURE COMPONENTS AS DETERMINANTS OF RETINAL MICRO-VESSEL DIAMETERS
JO  - Artery Research
SP  - 134
EP  - 134
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.115
DO  - 10.1016/j.artres.2013.10.115
ID  - Gu2013
ER  -