P3.12 PULSE WAVE VELOCITY AND DIABETES DURATION IN TYPE 2 DIABETES MELLITUS
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- 10.1016/j.artres.2013.10.100How to use a DOI?
- Abstract
Type 2 diabetes mellitus (T2DM) duration is related to early vascular aging and diabetic complications. Aortic stiffness is considered an integrated marker of the combined effect of cardiovascular risk factors, and could represent one of the links between diabetes and cardiovascular disease. To our knowledge, no study has been carried out to specially look at the relationship between aortic stiffness and T2DM duration. 618 patients (259 men) attending the Department of Internal Medicine of Tizi Ouzou Hospital (Algeria) underwent medical examination. Anthropometric, clinical and biological data were sampled; brachial blood pressure was measured, and aortic stiffness assessed from pulse wave velocity (PWV) was obtained. Diabetes duration collected from date of 1st diagnostic and analyzed by tertiles (<2 years; 2–9 years; >9 years). From lower to higher tertile of diabetes duration, age, brachial blood pressure and PWV increased, while diabetes control and renal function worsened (all p<0.01). After adjustment for age and blood pressure, microalbuminuria or insulin therapy, PWV was still higher in the higher duration tertile compare to the other 2. However the difference in PWV was negligeable after adjustment between the 2 lowest duration tertile. Diabetes duration is an important and independent determinant of PWV in type 2 diabetics. This is mainly true for higher durations, reflecting diabetes specific contributions to accelerated vascular stiffening. Furthermore, with aging, physiopathology of arterial stiffness involves other mechanisms that overwhelm diabetes duration.
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TY - JOUR AU - D. Agnoletti AU - S. Millasseau AU - A. Salah-Mansour AU - A.D. Protogerou AU - Y. Zhang AU - C. Borghi AU - J. Blacher AU - M. Safar PY - 2013 DA - 2013/11/11 TI - P3.12 PULSE WAVE VELOCITY AND DIABETES DURATION IN TYPE 2 DIABETES MELLITUS JO - Artery Research SP - 130 EP - 130 VL - 7 IS - 3-4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2013.10.100 DO - 10.1016/j.artres.2013.10.100 ID - Agnoletti2013 ER -