Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 126 - 126

P2.25 ECHOCARDIOGRAPHIC VALIDATION OF A NOVEL METHOD FOR NONINVASIVE ESTIMATION OF CARDIAC OUTPUT BASED ON PULSE CONTOUR ANALYSIS

Authors
T.G. Papaioannou1, 2, D. Soulis1, O. Vardoulis2, A.D. Protogerou3, P. Sfikakis3, N. Stergiopulos2, C. Stefanadis1
1Biomedical Engineering Unit, 1st Dept of Cardiology, Medical School, University of Athens, Athens, Greece
2Laboratory of Hemodynamics and Cardiovascular Technology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
3Cardiovascular Research Lab, 1st Dept. of Propaedeutic and Internal Medicine, Medical School, University of Athens, Athens, Greece
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.086How to use a DOI?
Abstract

Surgical or critically ill patients often require continuous assessment of cardiac output (CO) for diagnostic purposes or guiding therapeutic interventions. A new method of non-invasive estimation of CO, based on pressure wave analysis, has been recently developed, but its validity has been examined only in silico. Aim of this study was to evaluate the reproducibility, precision and accuracy of the “Systolic Volume Balance” method (SVB).

Methods: Twelve subjects underwent 2-D transthoracic echocardiography (Doppler) for CO measurement which was used as reference value. The application of SVB method required aortic pressure wave analysis and estimation of total arterial compliance (Ct). Aortic pulses were derived by mathematical transformation of radial pressure waves recorded by applanation tonometry (SphygmoCor). Ct was estimated by the “pulse pressure” method. The agreement, association, variability, bias and precision between the reference (Doppler) and estimated (SVB) values of CO were evaluated by Spearman correlation coefficient, intraclass correlation coefficient (ICC), coefficient of variation (CV), root mean square error (RPSE), mean difference, SD of differences (SDD), percentage error (PR) and Bland-Altman analysis.

Results: Both SVB and Doppler provided highly reproducible measures of CO when two repeated measurements were performed (ICC>0.9, SD of difference <0.4 L/min, CV<5%, PR<17%). CO estimation by the SVB method was comparable with the respective measure by Doppler indicating a good agreement and accuracy (Table).

Parameter Value
Mean difference (L/min) 0.780
Standard deviation of difference (L/min) 0.323
Limits of agreement (L/min) 0.15–1.41
Coefficient of variation (%) 13.0
Root mean squared error (L/min) 0.678
Spearman correlation coefficient 0.939
Intraclass correlation coefficient 0.797
Percentage error (%) 20
Table.

Accuracy and precision of CO estimation by the SVB method compared to the reference method (Doppler).

Conclusion: CO estimation by the SVB method is highly reproducible and accurate in comparison with the CO measurement by Doppler. Future studies, though, are required to assess the clinical utility of this method.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
126 - 126
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.086How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - T.G. Papaioannou
AU  - D. Soulis
AU  - O. Vardoulis
AU  - A.D. Protogerou
AU  - P. Sfikakis
AU  - N. Stergiopulos
AU  - C. Stefanadis
PY  - 2013
DA  - 2013/11/11
TI  - P2.25 ECHOCARDIOGRAPHIC VALIDATION OF A NOVEL METHOD FOR NONINVASIVE ESTIMATION OF CARDIAC OUTPUT BASED ON PULSE CONTOUR ANALYSIS
JO  - Artery Research
SP  - 126
EP  - 126
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.086
DO  - 10.1016/j.artres.2013.10.086
ID  - Papaioannou2013
ER  -