P1.20 PRESENCE OF INTRACRANIAL STENOSIS IN CORONARY PATIENTS IS ASSOCIATED WITH DETERIORATION OF ENDOTHELIAL FUNCTION

L. Ryliskyte; J. Valaikiene; J. Badariene; A. Laucevicius; A. Valaika; J. Dementaviciene; R. Puronaite; I. Butkuviene; A. Vaitkevicius

doi:10.1016/j.artres.2013.10.051

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Volume 7, Issue 3-4, September 2013, Pages 116 - 116

P1.20 PRESENCE OF INTRACRANIAL STENOSIS IN CORONARY PATIENTS IS ASSOCIATED WITH DETERIORATION OF ENDOTHELIAL FUNCTION

Authors

L. Ryliskyte¹^{, 2}, J. Valaikiene¹^{, 3}, J. Badariene¹^{, 2}, A. Laucevicius¹^{, 2}, A. Valaika¹^{, 4}, J. Dementaviciene¹^{, 5}, R. Puronaite¹, I. Butkuviene¹^{, 4}, A. Vaitkevicius¹^{, 3}

¹Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania

²Vilnius University, Centre of Cardiology and Angiology, Vilnius, Lithuania

³Vilnius University, Centre of Neurology, Vilnius, Lithuania

⁴Vilnius University, Centre of Cardiac Surgery, Vilnius, Lithuania

⁵Vilnius University, Centre of Radiology, Vilnius, Lithuania

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.051 How to use a DOI?
Abstract: Objectives: The objectives of this cross-sectional study was to determine the prevalence of extra/-intracranial stenosis in patients with severe coronary artery disease (CAD) and to analyze how endothelial function and arterial stiffness are related to the presence of intracranial stenosis.

Methods: We examined 57 patients with three vessels and/or left stem (LS) CAD. Brachiocephalic arteries were examined with extracranial and transcranial color-coded duplex sonography (ECCS, TCCS) and magnetic resonance angiography (MRA). Endothelial function was assessed as reactive hyperaemia index (RHI) by peripheral arterial tonometry (Endo-PAT). Carotid to femoral pulse wave velocity (cfPWV) and augmentation index (AIx@HR75) were assessed by applanation tonometry (Sphygmocor).

Results: From 57 pts (age 65±9, 44–82; 33% female), 30 pts (53%) were diagnosed with three vessels disease, 27 pts (47%) with LS disease with/without three vessels damage (21 and 6). ECCS revealed carotid plaques and stenoses in 105/114 vessels (92%). TCCS revealed at least one intracranial stenosis in 61.4% pts (35/57). Patients with intracranial stenosis had significantly lower RHI (1.82±0.38 vs. 2.19±0.59, p=0.029) and higher AIx@HR75 (35.72±7.83% vs. 28.06±12.18%). However, there was no significant difference in cfPWV between the patients with and without intracranial stenosis (10.38±2.18 m/s vs 10.43±2.98 m/s, ns).

Conclusions: Patients with severe CAD are at high risk to have a silent intracranial stenosis. In our study group, presence of intracrianal stenosis was associated with worse endothelial function but not higher arterial stiffness. Our finding suggests that in patients with generalized atherosclerosis endothelial dysfunction further contributes to the development of intracranial stenosis.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 116 - 116
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.051 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - L. Ryliskyte
AU  - J. Valaikiene
AU  - J. Badariene
AU  - A. Laucevicius
AU  - A. Valaika
AU  - J. Dementaviciene
AU  - R. Puronaite
AU  - I. Butkuviene
AU  - A. Vaitkevicius
PY  - 2013
DA  - 2013/11/11
TI  - P1.20 PRESENCE OF INTRACRANIAL STENOSIS IN CORONARY PATIENTS IS ASSOCIATED WITH DETERIORATION OF ENDOTHELIAL FUNCTION
JO  - Artery Research
SP  - 116
EP  - 116
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.051
DO  - 10.1016/j.artres.2013.10.051
ID  - Ryliskyte2013
ER  -

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