Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 112 - 112

P1.04 IMPACT OF WEIGHT-REDUCTION ON ARTERIAL STIFFNESS IN OBESE CHILDREN AND ADOLESCENTS: A ONE YEAR FOLLOW-UP STUDY

Authors
K.N. Hvidt1, 2, M.H. Olsen3, J.C. Holm2, H. Ibsen1
1Division of Cardiology, Department of Medicine, Copenhagen University Hospital Holbæk, Holbæk, Denmark
2The Children’s Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark
3Cardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Odense University Hospital, Odense, Denmark
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.035How to use a DOI?
Abstract

Introduction: Recently, in a cross-sectional study, we have found arterial stiffness assessed as carotid-femoral pulse wave velocity (cfPWV) to be reduced in obese children and adolescents. Therefore, we wanted to investigate whether weight-reduction influenced cfPWV independently of blood pressure (BP).

Methods: One hundred obese patients with age 10–18 years newly referred to the Children’s Obesity Clinic were investigated before and after one year of lifestyle intervention. CfPWV and augmentation index at heart rate 75 (AIx@HR75) were measured non-invasively using the SphygmoCor device. Weight-reduction was defined as ΔBMI z score <0. ClinicalTrials.org NCT01310088.

Results: Seventy-three of initial 104 patients were followed up (period: median 364 days (IQR 364–371)). ΔBMI z score was mean −0.26 +/− SD 0.41 (P<0.0001) in the total group, whereas fifty-five (75.3%) patients responded to treatment. Patients were divided by ΔBMI z score tertiles into high-, low- and non-responders. No difference was found in clinic BP in the total group at follow up or across responders (P=NS). ΔcfPWV was higher in the total group at follow up (0.26 +/−0.47 m/s, P<0.0001) with no difference across responders (P=0.87). Furthermore, ΔcfPWV showed no relationship with ΔBMI z score (P=0.82), neither when adjusting for gender, baseline age, heart rate and mean arterial pressure (P=0.99). Similar, ΔAIx@HR75 was higher at follow up (2.77 +/− 9.91, P=0.020) with no difference across responders (P=0.42).

Conclusion: No effect of weight-reduction was found on measures of arterial stiffness. In this respect, the higher arterial stiffness at follow up seems age-related.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
112 - 112
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.035How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - K.N. Hvidt
AU  - M.H. Olsen
AU  - J.C. Holm
AU  - H. Ibsen
PY  - 2013
DA  - 2013/11/11
TI  - P1.04 IMPACT OF WEIGHT-REDUCTION ON ARTERIAL STIFFNESS IN OBESE CHILDREN AND ADOLESCENTS: A ONE YEAR FOLLOW-UP STUDY
JO  - Artery Research
SP  - 112
EP  - 112
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.035
DO  - 10.1016/j.artres.2013.10.035
ID  - Hvidt2013
ER  -