P1.14 PULSE WAVE VELOCITY AND KIDNEY DISEASE

DOI

10.1016/j.artres.2013.10.045How to use a DOI?

Abstract

Increased arterial stiffness is one of the major alterations in arterial wall. It can be evaluated in non-invasively way by measuring the pulse wave velocity PWV in large arteries. Increased PWV is an independent predictor factor of cardiovascular complications in patients with hypertension and chronic kidney disease.

We conduct a 2 years prospective study between January 2003 and December 2004. In 161 patients we measured the PWV using an automatic device, the Complior (Colson, Paris). Patients where divided in 4 groups: 43 with polycystic kidney disease (PKD), 38 with primary chronic glomerulonephritis (PCGN), 40 patients with diabetes mellitus (DM) and 40 controls. The 4 groups were matched for age, sex and serum creatinine.

Results: we found a positive relationship between age and PWV in the different groups. There was a negative correlation between PWV and creatinine clearance. Among patients with chronic renal failure, PWV were correlated to serum phosphate level (p<0,02) and the product calcium X phosphate (p<0,006). In patients with DM, PWV was positively correlated to the level of hypertension and to the chronic renal failure (CRF). In patients with PCGN, PWV was positively correlated to the presence of vascular lesions on the kidney biopsy (p<0,004), to the level of hypertension and to the CRF. In the PKD group, PWV was correlated to the level of hypertension and to the CRF.

Conclusion: PWV is rather related to age, blood pressure and renal function than to type of nephropathy

Open Access

This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

TY  - JOUR
AU  - L. Rais
AU  - E. Abderrahim
AU  - R. Kheder
AU  - F. Ben-Moussa
AU  - A. Kheder
PY  - 2013
DA  - 2013/11/11
TI  - P1.14 PULSE WAVE VELOCITY AND KIDNEY DISEASE
JO  - Artery Research
SP  - 114
EP  - 114
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.045
DO  - 10.1016/j.artres.2013.10.045
ID  - Rais2013
ER  -