P1.25 SEVERITY OF ERECTILE DYSFUNCTION PREDICTS FUTURE EVENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF PROSPECTIVE STUDIES

DOI

10.1016/j.artres.2013.10.055How to use a DOI?

Abstract

Objectives: Evidence points towards a grading effect of the severity of ED in the predictive ability of this condition for CV events and all-cause mortality. We conducted a meta-analysis of all longitudinal studies for investigating the role of severity of ED in predicting risk of clinical events.

Methods: A comprehensive search of electronic databases was conducted through January 2013. Longitudinal studies that reported relative risk (RR) estimates with 95% confidence intervals (CI) of ED severity were included. Of the 5 studies included (101,147 participants, mean follow-up 6.4 years), all reported results on total CV events and 3 on all-cause mortality (98,212 individuals). Participants were grouped according to their ED severity in 3 different groups.

Results: The pooled relative risks (RRs) for total CV events were 1.32 (95% CI: 1.20 to 1.45, p<0.001) for men with moderate ED and 1.92 (95% CI: 1.37 to 2.68, p<0.001) for men with severe ED compared with men with no/mild ED (p=0.036 for comparison between men with moderate ED vs. severe ED). The pooled RRs for all-cause-mortality were 1.29 (95% CI: 1.01 to 1.65, p=0.043) for men with moderate ED and 1.83 (95% CI: 1.26 to 2.66, p=0.002) for men with severe ED compared with men with no/mild ED (p=0.127 for comparison between men with moderate ED vs. severe ED).

Conclusions: RR for CV events is higher at men with severe ED compared to men with moderate ED, implying a grading effect of ED severity and augmenting the pathophysiological link between ED and CV disease.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - D. Terentes-Printzios
AU  - C. Vlachopoulos
AU  - N. Ioakeimidis
AU  - K. Aznaouridis
AU  - C. Stefanadis
PY  - 2013
DA  - 2013/11/11
TI  - P1.25 SEVERITY OF ERECTILE DYSFUNCTION PREDICTS FUTURE EVENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF PROSPECTIVE STUDIES
JO  - Artery Research
SP  - 117
EP  - 117
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.055
DO  - 10.1016/j.artres.2013.10.055
ID  - Terentes-Printzios2013
ER  -