P1.17 AUTONOMIC NERVOUS ACTIVITY IN REACTIVE HYPEREMIA AND CONDUIT/RESISTANCE ARTERIAL ENDOTHELIAL FUNCTIONS IN PATIENTS WITH HYPERTENSION

DOI

10.1016/j.artres.2013.10.048How to use a DOI?

Abstract

Aims: Flow-mediated vasodilatation of the brachial artery (FMD), a marker of conduit arterial endothelial function, and reactive hyperemia index (RHI), a marker of resistance arterial endothelial function, measured by peripheral arterial tonometry, are known to be weakly associated with each other, however, the mechanisms underlying this weak association remain to be fully clarified.

We examined whether the autonomic nervous activation induced by the 5 minutes’ forearm clamping used to induce reactive hyperemia might exert any influence on the FMD and RHI in subjects with hypertension.

Methods and results: In 115 subjects with hypertension (age 61 ± 1 y/o), the FMD and RHI were measured simultaneously, and the heart rate variability (HRV), as a measure of the autonomic nervous activity, was calculated from the electrocardiographic recordings obtained before (5 minutes’ recording) and after the start of forearm clamping (10 minutes’ recording). The HRV parameters {low-frequency component (LF), high frequency component (HF), and the ratio (LF/HF) between the two} calculated from the records (15 minutes’ recording in total) were found to show no significant relationship with either the FMD or RHI. Then, the change in HRV induced by forearm clamping was measured as the percent change after the start of clamping relative to that before the start of clamping. A multivariate linear regression analysis with adjustments for confounding variables demonstrated that the RHI, but not FMD, was significantly associated with the percent change of the LF/HF associated with forearm clamping (beta = −0.222, p = 0.017).

Conclusion: Sympathetic nervous activation induced by 5-minutes forearm clamping to induce reactive hyperemia may affect the RHI, but not the FMD in subjects with hypertension. This difference may be one of the mechanisms underlying the existence of only a weak association between FMD and RHI.

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TY  - JOUR
AU  - H. Tomiyama
AU  - M. Odaira
AU  - A. Yamashina
PY  - 2013
DA  - 2013/11/11
TI  - P1.17 AUTONOMIC NERVOUS ACTIVITY IN REACTIVE HYPEREMIA AND CONDUIT/RESISTANCE ARTERIAL ENDOTHELIAL FUNCTIONS IN PATIENTS WITH HYPERTENSION
JO  - Artery Research
SP  - 115
EP  - 115
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.048
DO  - 10.1016/j.artres.2013.10.048
ID  - Tomiyama2013
ER  -