P127 Graded Cuff Compression Protocol to Induce Retrograde Shear Produces Proportionate Increment in Regional Arterial Compliance in Human Peripheral Artery

DOI

10.2991/artres.k.191224.153How to use a DOI?

Abstract

Background: External compression using pneumatic cuff inflation is a well-established model used to induce incremental changes in proximal retrograde flow and shear [1]. The mechanisms behind distal cuff compression leading to proximal increase in retrograde shear are not clear. We hypothesized that changes in regional arterial compliance due to external cuff compression lead to changes in pulse waveform and pulse wave reflections proximal to the cuff compression.

Methods: We calculated brachial-radial pulse wave velocity (br-PWV) as a measure of regional arterial compliance in the area undergoing external cuff compression. This was accomplished using simultaneous two-point applanation tonometry over the cubital fossa and the wrist (Figure 1), while pneumatic cuff compression at 25, 50, and 75 mmHg (3-minute compression, randomized order, separated by 5 minutes) was applied around the middle of the forearm in 9 healthy young subjects (27 ± 4 years). Br-PWV was calculated using foot detection of the pulse waveforms and brachial-radial distance.

Results: External cuff compression at 50 and 75 mmHg resulted in significant fall in br-PWV but not at 25 mmHg. Percentage change in br-PWV showed graded decrement with rise in pressure of external cuff compression (−1.16 ± 6.96 at 25 mmHg, −10.57 ± 3.80 at 50 mmHg and −35.59 ± 11.08; all comparisons p < 0.05).

Conclusion: External cuff compression leads to changes in regional arterial compliance, which possibly affect the pressure wave reflections and pressure waveform proximally, leading to changes in the blood flow pattern at the site.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Naaz Afreen
AU  - Dinu Chandran
AU  - Ashok Jaryal
AU  - Kishore Deepak
AU  - Sitikantha Roy
PY  - 2020
DA  - 2020/02/17
TI  - P127 Graded Cuff Compression Protocol to Induce Retrograde Shear Produces Proportionate Increment in Regional Arterial Compliance in Human Peripheral Artery
JO  - Artery Research
SP  - S168
EP  - S168
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.153
DO  - 10.2991/artres.k.191224.153
ID  - Afreen2020
ER  -