Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S177 - S177

P139 Does Early Life Programming Influence Arterial Stiffness and Central Hemodynamics in Adulthood? Could Birth Cohort Effects be of Importance?

Authors
Peter Nilsson*, Johannes Sperling
Lund University, Department of Clinical Sciences, Skane University Hospital, Malmo, Sweden
*Corresponding author. Email: Peter.Nilsson@med.lu.se
Corresponding Author
Peter Nilsson
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.162How to use a DOI?
Abstract

Objective: Our aim was to investigate possible associations between birth weight (BW) and adult carotid-femoral Pulse Wave Velocity (cfPWV) and augmentation pressure index (AIx).

Design: This study including 1598 participants, 340 elderly subjects and 1258 young-middle aged subjects from the Malmö Offspring Study with data on birth weight and gestational age (GA). Participants underwent cfPWV and AIx measurements with Sphygmocor® (AtCor, Australia). Analysis of data was performed with multiple linear regression models with adjustments for age, sex, GA, and risk factors. Furthermore, comparisons were made between participants born prematurely or at term, or born small-for-gestational-age (SGA) or appropriate-for-gestational-age (AGA).

Results: Birth weight was positively associated with cfPWV after full adjustment (b = 0.057; p < 0.001), Figure 1, a finding that remained significant in the younger age group 18–27 years (b = 0.138, p = 0.008). Furthermore, birth weight was inversely associated with AIx (b = −0.058, p = 0.001). Subjects born SGA had significantly higher AIx (p = 0.007) and MAP (p = 0.037) compared to AGA born. Preterm-born subjects showed significantly higher systolic blood pressure compared to term-born (p = 0.034). Also, BW was inversely associated with MAP (b = −0.058, p = 0.017) and SBP (b = −0.047, p = 0.031), respectively.

Figure 1

Simple regression of birth weight and pulse wave velocity.

Conclusion: Our findings suggest that changes in total peripheral resistance, rather than decreased arterial stiffness, may explain the observed inverse association between birth weight and SBP. Furthermore, the association between birth weight and cfPWV, shown strongest in the youngest age group (birth cohort), could possibly be explained by increasing maternal overweight/obesity. This calls for screening of risk factors in subjects with adverse conditions at birth.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S177 - S177
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.162How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Peter Nilsson
AU  - Johannes Sperling
PY  - 2020
DA  - 2020/02/17
TI  - P139 Does Early Life Programming Influence Arterial Stiffness and Central Hemodynamics in Adulthood? Could Birth Cohort Effects be of Importance?
JO  - Artery Research
SP  - S177
EP  - S177
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.162
DO  - 10.2991/artres.k.191224.162
ID  - Nilsson2020
ER  -