Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S56 - S56

P13 Role of Adipose Tissue and Skeletal Muscle in Peripheral Arterial Disease

Authors
Joana Ferreira1, *, Pedro Cunha2, Alexandre Carneiro3, Cristina Cunha2, Cristina Silva2, Isabel Vila2, Amílcar Mesquita4, Jorge Cotter4
1Hospital da Senhora da Oliveira-Guimaraes
2Hospital da Senhora da Oliveira
3Centro Hospitalar de Trás-os-Montes e Alto Douro
4Hospital da Senhora da Oliveira, Guimarães, Portugal
*Corresponding author. Email: joana222@gmail.com
Corresponding Author
Joana Ferreira
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.048How to use a DOI?
Abstract

Background: Peripheral arterial disease (PAD) is a manifestation of atherosclerosis. Adipose tissue (AT) and skeletal muscle (SM) are endocrine organs with vascular effects. The objective is to compare the quantity and function of AT and SM between two groups: intermittent claudication (IC) and critical limb ischemia (CLI).

Methods: A prospective observational study is being performed. A transverse CT image at lower border the third lumbar vertebra was used to quantify the SM, visceral and subcutaneous AT. The SM function was inferred with the determination of hand strength using a Jamar® hydraulic hand dynamometer.

Results: From December 2018 to May 2019, 44 PAD were studied: 31 with IC (24 male; age: 67 10, 29 years) and 13 CLI (7 male; age: 70, 62 6, 74 years). CLI have a lower quantity of subcutaneous AT and higher quantity of visceral and total AT, determined on the CT scan (subcutaneous AT: 16564,75 7600,00 cm2 IC versus 16067,42 10187,33 cm2 CLI p = 0.03; visceral AT: 17212,20 10096, 30 cm2 IC versus 18904,85 10189,04 cm2 CLI p = 0,03; Total AT: 33222,08 15459,33 cm2 IC versus 57320,00 52538,78 cm2 CLI p = 0.03). CLI had lower SM strength and density (muscle strength right hand: 22,62 8,20 Kgf IC versus 16,38 7,84 Kgf CLI p = 0,02; SM strength left hand: 21,98 8,98 Kgf IC versus 16,37 8,35 Kgf CLI p = 0,04; SM density: 20,44 11,73 HU IC versus 9,04 28,47 HU CLI p = 0,01) No differences were found in the SM quantity (15120,87 3199,35 cm2 IC versus 15322,57 5315,31 cm2 CLI p = 0.44).

Conclusion: CLI have a higher quantity of visceral, total AT and lower quantity of subcutaneous AT, SM function and density.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S56 - S56
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.048How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Joana Ferreira
AU  - Pedro Cunha
AU  - Alexandre Carneiro
AU  - Cristina Cunha
AU  - Cristina Silva
AU  - Isabel Vila
AU  - Amílcar Mesquita
AU  - Jorge Cotter
PY  - 2020
DA  - 2020/02/17
TI  - P13 Role of Adipose Tissue and Skeletal Muscle in Peripheral Arterial Disease
JO  - Artery Research
SP  - S56
EP  - S56
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.048
DO  - 10.2991/artres.k.191224.048
ID  - Ferreira2020
ER  -