Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S93 - S93

P52 The Long-term Effects of Transcatheter Aortic Valve Implantation on Aortic Stiffness

Authors
Vasiliki Gardikioti1, *, Dimitrios Terentes-Printzios1, Charalambos Vlachopoulos1, Konstantinos Toutouzas1, Evangelia Christoforatou1, Maria Xanthopoulou1, Georgios Benetos1, Georgios Latsios1, Gerasimos Siasos1, Evangelia Mpei1, Manolis Vavuranakis1, Dimitrios Tousoulis1
1First Department of Cardiology, Hippokration General Hospital, Athens, Greece
*Corresponding author. Email: gardikiotiv@gmail.com
Corresponding Author
Vasiliki Gardikioti
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.083How to use a DOI?
Abstract

Purpose/Background/Objectives: Aortic stiffness and hemodynamics are independent predictors of adverse cardiovascular events. Transcatheter aortic valve implantation (TAVI) is growingly used in high surgical risk patients with aortic valve stenosis. We sought to investigate the effect of TAVI on aortic stiffness.

Methods: Fifty-five high-risk patients (mean age 79.5 ± 8.8 years, 46% males) with severe symptomatic aortic stenosis undergoing TAVI were included. Arterial stiffness was estimated through carotid-femoral pulse wave velocity (cfPWV). Measurements were conducted prior to the implantation, at discharge and 1 year post-TAVI.

Results: Prior to the implantation, cfPWV was 7.5 ± 1.4 m/s for the overall population. There was a statistically significant increase in measurements of aortic stiffness at discharge (7.5 ± 1.4 vs 8.3 ± 1.9 m/s for cfPWV with p = 0.043) without a statistically significant change in SBP (p = NS) (Figure 1). There was also a significant increase in cfPWV (8.7 ± 1.8 m/s) after 1 year compared to the pre-procedural assessment (p = 0.001). We also observed a non-significant increase in peripheral SBP at 1 year compared to SBP measurements at baseline and at discharge (153 ± 24 m/s vs 147 ± 21and 148 ± 22 m/s, respectively; p = 0.319) and these changes were independent of age and gender (Figure 1).

Conclusion: Our study shows that both shortly as well as in the long-term after TAVI subjects experience an increase in aortic stiffness that is independent of changes in SBP. These findings further elucidate the hemodynamic consequences and provide evidence of a possible long-standing repercussion of TAVI.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S93 - S93
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.083How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Vasiliki Gardikioti
AU  - Dimitrios Terentes-Printzios
AU  - Charalambos Vlachopoulos
AU  - Konstantinos Toutouzas
AU  - Evangelia Christoforatou
AU  - Maria Xanthopoulou
AU  - Georgios Benetos
AU  - Georgios Latsios
AU  - Gerasimos Siasos
AU  - Evangelia Mpei
AU  - Manolis Vavuranakis
AU  - Dimitrios Tousoulis
PY  - 2020
DA  - 2020/02/17
TI  - P52 The Long-term Effects of Transcatheter Aortic Valve Implantation on Aortic Stiffness
JO  - Artery Research
SP  - S93
EP  - S93
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.083
DO  - 10.2991/artres.k.191224.083
ID  - Gardikioti2020
ER  -