P96 Soluble Receptor for Advanced Glycation End-products Independently Influenced Individual Age-dependent Increase of Arterial Stiffness

DOI

10.2991/artres.k.191224.124How to use a DOI?

Abstract

Background: Soluble receptors for advanced glycation end-products (sRAGEs) have been suggested to have a protective role neutralizing the advanced glycation end-products (AGEs) and their pathological effect on vessel walls. We aimed to investigate the association between circulating concentrations of sRAGEs and dynamic of arterial wall stiffening as a manifestation of vascular ageing in general population.

Methods: In a prospective cohort study, we longitudinally followed 530 general-population-based subjects (subsample of Czech post-Monica study). Aortic pulse wave velocity (PWV) was measured twice (at baseline and after ≈8 years of follow-up) using a Sphygmocor device (AtCor Medical Ltd.) and intra-individual change of PWV per year (ΔPWV/year) was calculated. Concentrations of sRAGE were assessed at baseline by ELISA methods (R& Systems).

Results: Average ΔPWV/year significantly increased across the sRAGE quintiles (p = 0.0008) and drop by one sRAGE quintile was associated with ≈21% increase in the relative risk of accelerated age-dependent stiffening (ΔPWV/year ≥0.2 m/sec). In a categorized manner, subjects in the bottom quintile of sRAGE (<889.74 pg/mL) had fully adjusted odds ratio of accelerated stiffening 1.72 (95% CI: 1.06–2.79), p = 0.028, while those with high sRAGE concentrations (≥1695.2 pg/mL) showed opposite effect [with odds ratio 0.55 (95% CI: 0.33–0.90), p = 0.017].

Conclusion: Circulating status of sRAGE independently influenced individual progression of arterial stiffness overt time. This finding strongly supports hypothesis, that high sRAGE have protective role against vascular ageing.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Július Gelžinský
PY  - 2020
DA  - 2020/02/17
TI  - P96 Soluble Receptor for Advanced Glycation End-products Independently Influenced Individual Age-dependent Increase of Arterial Stiffness
JO  - Artery Research
SP  - S137
EP  - S137
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.124
DO  - 10.2991/artres.k.191224.124
ID  - Gelžinský2020
ER  -