P26 Ascending Aorta Longitudinal Strain is not Altered in Bicuspid Aortic Valve Patients

Andrea Guala; Lydia Dux-Santoy; Gisela Teixido-Tura; Aroa Ruiz-Muñoz; Laura Madrenas; Minerva Gandara; Augusto Sao-Aviles; Filipa Valente; Laura Galian-Gay; Laura Gutierrez; Teresa Gonzalez-Alujas; Ignacio Ferreira; Arturo Evangelista; Jose Rodriguez-Palomares

doi:10.2991/artres.k.191224.060

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Volume 25, Issue Supplement 1, December 2019, Pages S69 - S69

P26 Ascending Aorta Longitudinal Strain is not Altered in Bicuspid Aortic Valve Patients

Authors

Andrea Guala¹, Lydia Dux-Santoy¹, Gisela Teixido-Tura², Aroa Ruiz-Muñoz¹, Laura Madrenas¹, Minerva Gandara¹, Augusto Sao-Aviles¹, Filipa Valente², Laura Galian-Gay², Laura Gutierrez², Teresa Gonzalez-Alujas², Ignacio Ferreira², Arturo Evangelista¹, Jose Rodriguez-Palomares²

¹Vall d'Hebron Institute of Research, Barcelona, Spain

²Department of Cardiology, Vall d'Hebron Hospital, Barcelona, Spain

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.060 How to use a DOI?
Abstract: Background: Impaired ascending aorta (AAo) longitudinal strain, a marker of AAo deformation due to aorto-ventricular mechanical interaction, is related to progressive dilation and aortic events in Marfan syndrome [1]. Whether the high prevalence of dilation in bicuspid aortic valve (BAV) is due to intrinsically-altered aortic wall properties [2] or hemodynamic [3] is widely-discussed [4]. Whether AAo longitudinal strain is altered in BAV patients has never been assessed.

Methods: One-hundred five BAV patients, 47 patients with AAo dilation and tricuspid aortic valve (TAV) and 31 healthy volunteers, free from previous cardiac/aortic surgery, dissection and moderate/severe valvular disease had cine MR images to compute AAo longitudinal strain [1].

Results: Compared to healthy volunteers, the 25 non-dilated (z-score < 2) BAV patients were older (p < 0.001), had higher systolic blood pressure (SBP, p = 0.001), clinically-meaningless (BAV z-score = 0.74 ± 1.1) larger AAo diameter (p < 0.001) and similar diastolic blood pressure (DBP), BSA, stroke volume and heart rate. AAo longitudinal strain was lower in non-dilated BAV compared to healthy volunteers (13.7 vs 10.3%, p = 0.008) but this difference was not significant after correction for age. Compared to dilated TAV, dilated BAV patients were younger (p < 0.001), had lower BSA (p = 0.010) and AAo diameter (p = 0.003), higher DBP (p = 0.032) and similar SBP, stroke volume and heart rate. AAo longitudinal strain was higher in dilated BAV compared to dilated TAV (10 vs 7.2%, p < 0.001) but this difference was not significant after correction for age, BSA and DBP.

Conclusion: AAo longitudinal strain is similar in BAV and TAV matched for aortic dilation.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]A Guala, G Teixidó-Tura, J Rodríguez-Palomares, A Ruiz-Muñoz, L Dux-Santoy, N Villalva, et al., Proximal aorta longitudinal strain predicts aortic root dilation rate and aortic events in Marfan syndrome, Eur Heart J, Vol. 40, 2019, pp. 2047-55.

[2]A Guala, J Rodríguez-Palomares, L Dux-Santoy, G Teixido-Tura, G Maldonado, L Galian, et al., Influence of aortic dilation on the regional aortic stiffness of bicuspid aortic valve assessed by 4-dimensional flow cardiac magnetic resonance: comparison with Marfan Syndrome and degenerative aortic aneurysm, JACC Cardiovasc Imaging, Vol. 12, 2019, pp. 1020-9.

[3]JF Rodríguez-Palomares, L Dux-Santoy, A Guala, R Kale, G Maldonado, G Teixido-Tura, et al., Aortic flow patterns and wall shear stress maps by 4D-flow cardiovascular magnetic resonance in the assessment of aortic dilatation in bicuspid aortic valve disease, J Cardiovasc Magn Reson, Vol. 20, 2018, pp. 28.

[4]E Girdauskas, MA Borger, MA Secknus, G Girdauskas, and T Kuntze, Is aortopathy in bicuspid aortic valve disease a congenital defect or a result of abnormal hemodynamics? A critical reappraisal of a one-sided argument, European Journal of Cardio-thoracic Surgery, Vol. 39, 2011, pp. 809-14.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S69 - S69
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.060 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Andrea Guala
AU  - Lydia Dux-Santoy
AU  - Gisela Teixido-Tura
AU  - Aroa Ruiz-Muñoz
AU  - Laura Madrenas
AU  - Minerva Gandara
AU  - Augusto Sao-Aviles
AU  - Filipa Valente
AU  - Laura Galian-Gay
AU  - Laura Gutierrez
AU  - Teresa Gonzalez-Alujas
AU  - Ignacio Ferreira
AU  - Arturo Evangelista
AU  - Jose Rodriguez-Palomares
PY  - 2020
DA  - 2020/02/17
TI  - P26 Ascending Aorta Longitudinal Strain is not Altered in Bicuspid Aortic Valve Patients
JO  - Artery Research
SP  - S69
EP  - S69
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.060
DO  - 10.2991/artres.k.191224.060
ID  - Guala2020
ER  -

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