P98 Impaired Pulmonary Function is Associated with Increased Cardio-ankle Vascular Index in Hiv Patients in Ghana

Kwame Yeboah; Latif Musah; Samuel Essel; Bartholomew Dzudzor; J Kennedy Cruickshank

doi:10.2991/artres.k.191224.126

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Volume 25, Issue Supplement 1, December 2019, Pages S139 - S139

P98 Impaired Pulmonary Function is Associated with Increased Cardio-ankle Vascular Index in Hiv Patients in Ghana

Authors

Kwame Yeboah¹^{, *}, Latif Musah¹, Samuel Essel¹, Bartholomew Dzudzor¹, J Kennedy Cruickshank²

¹Medical School, University of Ghana, Ghana

²Cardiovascular Medicine Group, Division of Diabetes and Nutrition, King’s College and King’s Health Partners, London, UK

^*Corresponding author. Email: melvinky@gmail.com

Corresponding Author

Kwame Yeboah

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.126 How to use a DOI?
Abstract: Aim: Patients with HIV have increased cardiovascular risk and pulmonary defects. We investigated the association between impaired pulmonary function (IPF) and arterial stiffening measured by the cardio-ankle vascular index (CAVI) in Ghanaian HIV patients.

Method: Spirometry was used to measure pulmonary indices; forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) in 79 HIV patients on treatment, 75 HIV treatment naïve patients and 78 non-HIV controls. We also used FEV1/FVC < lower limit of normal as a further index. Arterial stiffness was measured as CAVI using the Vasera device.

Results: Compared to non-HIV controls, CAVI was higher in treatment naïve (6.9 ± 1.4 vs 6.3 ± 1.1 units, p < 0.01) and HIV patients on treatment (8.1 ± 1.4, vs 6.3 ± 1.1, p < 0.01). IPF was detected in 12 (15.2%) HIV patients on treatment, 8 (10.7%) treatment naïve HIV patients and 5 (6.4%) non-HIV controls. Compared to those without IPF, IPF patients had higher CAVI in non-HIV controls (6.5 ± 1.1 vs 5.7 ± 0.8, p < 0.01), treatment naïve HIV patients (7.1 ± 1.8 vs 6.6 ± 1.4, p = 0.023) and HIV patients on treatment (7.8 ± 1.4 vs 8.7 ± 1.2, p < 0.01). In multivariable logistic regression analysis, IPF was independently associated with CAVI [adjusted OR = 1.33 (1.15 – 1.89), p = 0.037] after adjustment for age [1.21 (0.98 – 2.14), p = 0.11], male sex [0.42 (0.32 – 0.91), p = 0.035], current/former smoking status [1.43 (0.47 – 4.01), p = 0.75] and history of tuberculosis infection [1.96 (1.08 – 3.12), p < 0.01].

Conclusion: Ghanaian HIV patients have a high prevalence of impaired respiratory function and arterial stiffening, and these indices are associated with each other.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S139 - S139
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.126 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Kwame Yeboah
AU  - Latif Musah
AU  - Samuel Essel
AU  - Bartholomew Dzudzor
AU  - J Kennedy Cruickshank
PY  - 2020
DA  - 2020/02/17
TI  - P98 Impaired Pulmonary Function is Associated with Increased Cardio-ankle Vascular Index in Hiv Patients in Ghana
JO  - Artery Research
SP  - S139
EP  - S139
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.126
DO  - 10.2991/artres.k.191224.126
ID  - Yeboah2020
ER  -

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