P78 Endothelial Dysfunction and Arterial Stiffness During Type 2 Diabetes

Maimouna Toure; Magid Hallab; Souleymane Thiam; Sheikh AB Mane; Farid Belem; Abdoulaye Samb

doi:10.2991/artres.k.191224.108

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Volume 25, Issue Supplement 1, December 2019, Pages S121 - S121

P78 Endothelial Dysfunction and Arterial Stiffness During Type 2 Diabetes

Authors

Maimouna Toure¹, Magid Hallab²^{, *}, Souleymane Thiam³, Sheikh AB Mane¹, Farid Belem¹, Abdoulaye Samb¹

¹Laboratory of Physiology Human and Functional Explorations, FMPO, UCAD, Senegal

²Clinique Bizet, 75008 Paris, France

³Laboratory of Biochemistry and Molecular Biology, OPCF, UCAD, Dakar, Senegal

^*Corresponding author. Email: magid.hallab@gmail.com

Corresponding Author

Magid Hallab

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.108 How to use a DOI?
Abstract: Objective: We aimed to study Endothelial dysfunction and Arterial Stiffness in Diabetes mellitus.

Methods: 29 women with type 2 diabetes and 8 non-diabetic controls were included. Vascular function was studied with pOpmetre^® (Axelife SAS-France) to assess the foot to toe Pulse Wave Velocity; and EndoPAT2000^® (ITAMAR-Israel) to measure endothelial vasodilatation dependent by measurement of reactive hyperhemic index (RHI).

Results: Diabetics were 56 ± 6 years vs 47 ± 9 years. Mean diabetes duration was 9.07 ± 6.15 years. RHI was normal in all controls (1.94 ± 0.68) and abnormal in 51.72% of diabetics (1.83 ± 0.12). An abnormal ftPWV was found in 38% of diabetic subjects (11.6 ± 7.7 m/s) vs 12% of controls (7.7 ± 2.3 m/s, normal <10 m/s). There was a positive correlation between ftPWV and age (r = 0.25; p = 0.001); ftPWV and duration of diabetes (r = 0.12; p = 0.03). At the same time we found a negative correlation between RHI and fasting blood glucose (r = −0.46; p = 0.01), HbA1c (r = −0.37; p = 0.04), triglycerides (r = −0.49; p = 0.03) and total cholesterol (r = −0.37; p = 0.04). In a rapid and non-invasive way, we found endothelial dysfunction in 51.72% of diabetics and arterial stiffness in 38% of them.

Conclusion: During diabetes, endothelial dysfunction and arterial stiffness are therefore dependent on the glycemic balance, the duration of diabetes and lipid parameters. However, these two parameters appear independently and differently associated with diabetic disease.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S121 - S121
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.108 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Maimouna Toure
AU  - Magid Hallab
AU  - Souleymane Thiam
AU  - Sheikh AB Mane
AU  - Farid Belem
AU  - Abdoulaye Samb
PY  - 2020
DA  - 2020/02/17
TI  - P78 Endothelial Dysfunction and Arterial Stiffness During Type 2 Diabetes
JO  - Artery Research
SP  - S121
EP  - S121
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.108
DO  - 10.2991/artres.k.191224.108
ID  - Toure2020
ER  -

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