P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2

Mayra Jimenez; Fernando Grover; Marycruz Barocio; Ernesto Cardona; Patricia Quezada; Jhonatan Trujillo; David Cardona; Carlos Ramos

doi:10.2991/artres.k.191224.081

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 25, Issue Supplement 1, December 2019, Pages S91 - S91

P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2

Authors

Mayra Jimenez^*, Fernando Grover, Marycruz Barocio, Ernesto Cardona, Patricia Quezada, Jhonatan Trujillo, David Cardona, Carlos Ramos

Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

^*Corresponding author. Email: mayrajimc16@gmail.com

Corresponding Author

Mayra Jimenez

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.081 How to use a DOI?
Abstract: Purpose/Background/Objectives: Hypertension (HAS) represents 9.4 million deaths from all the cases of cardiovascular disease worldwide [1]. The pulse wave velocity (PWV) and some hemodynamic parameters have been associated with this outcome [2,3]. Losartan, as well as amlodipine, have shown benefits on hemodynamic parameters [4,5] however, it is unknown if losartan/amlodipine combination is better than losartan as a monotherapy. We evaluated losartan/amlodipine effect in a fixed combination versus losartan on hemodynamic and arterial stiffness parameters in patients with systemic arterial hypertension.

Design and Methods: We conducted a randomized, double-blind study in 28 hypertensive patients according to AHA criteria 2017 [6]. 14 patients received losartan 100 mg per day and 14 losartan/amlodipine 100/5 mg per day, for 8 weeks. Hemodynamic parameters and arterial stiffness measurement were performed with a Mobil-O-Graph^® [7].

Results: The combination of losartan/amlodipine improved hemodynamic and arterial stiffness parameters compared with losartan, reducing peripheral vascular resistance (RVP) (0.10 ± 0.08 vs 0.05 ± 0.08), PWV (0.52 ± 0.45 vs 0.33 ± 0.359), daytime PWV (7.24 ± 0.90 vs 7.61 ± 1.03), nocturnal PWV (6.86 ± 0.96 vs 7.27 ± 1.17) and diastolic blood pressure (DBP) (11.21 ± 6.15 vs 5.92 ± 7.65).d)

Conclusion: We did not find differences between single or combined medication in terms of BP reduction. However, arterial stiffness parameters were better in the combined therapy.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]K Dasgupta, RR Quinn, KB Zarnke, DM Rabi, P Ravani, SS Daskalopoulou, et al., The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension, Can J Cardiol, Vol. 30, 2014, pp. 485-501.

[2]JD Parikh, KG Hollingsworth, V Kunadian, A Blamire, and GA MacGowan, Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging, BMC Cardiovasc Disord, Vol. 16, 2016, pp. 50.

[3]Y Aoka, N Hagiwara, and H Kasanuki, Heterogeneity of hemodynamic parameters in untreated primary hypertension, and individualization of antihypertensive therapy based on noninvasive hemodynamic measurements, Clin Exp Hypertens, Vol. 35, 2013, pp. 61-6.

[4]VK Raman, C Tsioufis, M Doumas, and V Papademetriou, Renal denervation therapy for drug-resistant hypertension: does it still work?, Curr Treat Options Cardiovasc Med, Vol. 19, 2017, pp. 39.

[5]M Kurata, T Okura, S Watanabe, J Irita, D Enomoto, M Johtoku, et al., Effects of amlodipine and candesartan on arterial stiffness estimated by cardio-ankle vascular index in patients with essential hypertension: a 24-week study, Curr Ther Res Clin Exp, Vol. 69, 2008, pp. 412-22.

[6]PK Whelton, RM Carey, WS Aronow, DE Casey, KJ Collins, C Dennison Himmelfarb, et al., 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, Journal of the American College of Cardiology, 2017.

[7]Mobil-O-Graph®, I.E.M. Industrielle Entwicklung Medizintechnik GmbH, Germany.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S91 - S91
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.081 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Mayra Jimenez
AU  - Fernando Grover
AU  - Marycruz Barocio
AU  - Ernesto Cardona
AU  - Patricia Quezada
AU  - Jhonatan Trujillo
AU  - David Cardona
AU  - Carlos Ramos
PY  - 2020
DA  - 2020/02/17
TI  - P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2
JO  - Artery Research
SP  - S91
EP  - S91
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.081
DO  - 10.2991/artres.k.191224.081
ID  - Jimenez2020
ER  -

download .riscopy to clipboard