P58 Structured Exercise Training is Associated with Better Post Occlusive Reactive Hyperaemia in Skeletal Muscle Measured using Near Infrared Spectroscopy (NIRS)

DOI

10.2991/artres.k.191224.089How to use a DOI?

Abstract

Background: Participation in structured exercise training may improve microvascular function. Post occlusive reactive hyperaemia (PORH) is a measure of microvascular function in skeletal muscle and can be assessed using near-infrared spectroscopy (NIRS). We examined PORH following a short and a long arterial occlusion to test whether individuals who participate in more structured exercise have better PORH.

Methods: 18 healthy volunteers (mean age = 23.1 (standard deviation (SD) = 4.9 y), male = 12) underwent 30 s and 5 minute arterial occlusions of the left lower leg using a cuff inflated to supra-systolic pressure. Change in oxygenated haemoglobin concentration (oxy-Hb) was measured from the gastrocnemius using NIRS (Artinis, Netherlands). PORH was measured as time to 50% (T₅₀) of peak oxy-Hb following cuff release and a lower T₅₀ indicates a better response. Exercise participation was categorised into high (n = 12) or low (n = 6) based on self-reported hours of structured exercise per week (high ≥4 hr per week). Results are given as median (IQR) and statistical comparison was by the Mann Whitney U-Test.

Results: High exercise participants had a greater PORH response than low exercise participants (T₅₀: 8.0 (6.2, 9.5)s vs 12.5 (8.6, 27.2)s, p = 0.04; Figure 1a). The hyperaemic response to 30 s occlusion was also better in the high exercise group (T₅₀: 2.4 (1.7, 6.6)s vs 4.3 (3.6, 4.9)s p = 0.17; Figure 1b), although this difference was not statistically significant.

Figure 1

a & b Boxplots comparing the PORH response in low and high exercise groups. Data are 12.5 (8.6, 27.2)s and 8.0 (6.2, 9.5)s for the low exercise group and the high exercise group respectively in the 5 minute occlusion compared with 4.3 (3.6, 4.9)s and 2.4 (1.7, 6.6)s in the 30 s occlusion. p-values are calculated using a Mann Whitney U-Test.

Conclusion: Individuals who participate in more structured exercise have evidence of improved microvascular function in skeletal muscle.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Chirag Rao
AU  - Siana Jones
AU  - Khadija Ezzi
AU  - Alun Hughes
PY  - 2020
DA  - 2020/02/17
TI  - P58 Structured Exercise Training is Associated with Better Post Occlusive Reactive Hyperaemia in Skeletal Muscle Measured using Near Infrared Spectroscopy (NIRS)
JO  - Artery Research
SP  - S99
EP  - S99
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.089
DO  - 10.2991/artres.k.191224.089
ID  - Rao2020
ER  -