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Volume 25, Issue Supplement 1, December 2019, Pages S95 - S95

P54 Age-specific, Pressure-independent Acute Changes in Carotid-femoral Pulse Wave Velocity During Head-up Tilt

Authors
Giacomo Pucci1, 2, *, Alberto Avolio3, Bart Spronck4, 5, Gaetano Vaudo6, Fabio Anastasio7, Anton H. Van den Meiracker A.H2, Francesco U.S. Mattace-Raso2
1Department of Medicine, University of Perugia - Unit of Internal Medicine, Terni University Hospital, Terni, Italy
2Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands
3Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
4Department of Biomedical Engineering Yale University, New Haven, CT, United States
5Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
6Department of Medicine, University of Perugia, Unit of Internal Medicine, Terni University Hospital, Terni, Italy
7Unit of Cardiology, ASST-VAL Hospital of Sondrio, Sondrio, Italy
*Corresponding author. Email: giacomo.pucci@gmail.com
Corresponding Author
Giacomo Pucci
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.085How to use a DOI?
Abstract

Introduction: Acute, gravity-induced blood pressure (BP) changes during head-up tilt may generate concomitant variations in carotid-femoral pulse wave velocity (cf-PWV). We aimed to separate the pressure-dependent and -independent components of cf-PWV changes observed during head-up tilt.

Methods: 30 healthy individuals (age 48 ± 18 years (mean ± SD), 38% males, BP 130/74 ± 12/8 mmHg) underwent head-up passive tilting at a = 0°, 30°, and 60°. BP was taken at the upper arm, constantly kept at heart level. Aortic BP was reconstructed from radial tonometry (SphygmoCor). Stiffness index b0 was estimated at 0°. 1 Assumptions: [1] from MRI2, the effective cf-PWV travel distance (ETD, 80% of straight carotid-to-femoral distance) begins at heart level; [2] the change in DBP along the aorta is predictable from the hydrostatic pressure gradient (0.73 mmHg/cm) 3; [3] cf-PWV and hydrostatic pressure relate linearly, hence predicted cf-PWV can be calculated as the average of aortic (PWVaorta, using b0 and aortic DBP) and femoral (PWVfem, using b0 and femoral DBP, corresponding to aortic DBP + (ETD × sin(a)*0.73)) PWVs.

Results: Both young (24–48 years) and old (48–82 years) individuals showed increasing trends for peripheral SBP, DBP, PP, and central DBP with tilting; central SBP remained unchanged. Heart rate (HR) and cf-PWV increased with body tilt in both groups (Figure, left). b0 linearly correlated with age (R = 0.70, p < 0.01). After adjustment for HR4, observed-vs-predicted cf-PWV exponentially increased as a function of age (R2 = 0.38, p < 0.01 for quadratic equation, p = 0.04, vs. linear; Figure, right).

Conclusion: With aging, the acute relationship between BP and cf-PWV becomes progressively nonlinear.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]B Spronck et al., J Hypertens, Vol. 35, 2017, pp. 98-104.
[2]J Sugawara et al., Am J Hypertens, Vol. 29, 2016, pp. 1237-44.
[3]B Gavish et al., J Hypertens, Vol. 29, 2011, pp. 2099-104.
[4]I Tan et al., Hypertension, Vol. 68, 2016, pp. 236-42.
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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S95 - S95
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.085How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Giacomo Pucci
AU  - Alberto Avolio
AU  - Bart Spronck
AU  - Gaetano Vaudo
AU  - Fabio Anastasio
AU  - Anton H. Van den Meiracker A.H
AU  - Francesco U.S. Mattace-Raso
PY  - 2020
DA  - 2020/02/17
TI  - P54 Age-specific, Pressure-independent Acute Changes in Carotid-femoral Pulse Wave Velocity During Head-up Tilt
JO  - Artery Research
SP  - S95
EP  - S95
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.085
DO  - 10.2991/artres.k.191224.085
ID  - Pucci2020
ER  -