Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S76 - S76

P35 Education Level may Modify the Association Between Cardiac Index and Cognitive Function Among Elders with Normal Ejection Function

Authors
Cheng Hao-Min1, 2, Chuang Shao-Yuan3, Ko Yu-Ting, Liao Chao-Feng1, Pan Wen-Harn4, Liu Wen-Ling3, Hung Chen-Ying5, Chen Chen-Huan2, 3
1Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.
2Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
3Public Health Sciences Institute, National Health Research Institutes, Miaoli, Taiwan, R.O.C.
4Institutes of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C.
5Taipei Veterans Hospital, Hsinchu Branch, Hsinchu, Taiwan, R.O.C.
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.067How to use a DOI?
Abstract

Background: Lower cardiac index (CI) in elders without clinical heart disease has been associated with impaired cognitive function and incident dementia. In the present study, we investigated the modulating effects of education level and arterial stiffness on the association between CI and cognitive function among older adults.

Methods: A total of 723 elders (≥60 years, 50.1% female) with normal left ventricular ejection-fraction (≥50%) were identified from the Cardiovascular Diseases Risk Factor Two-Township Study. CI was calculated from the Doppler-derived stroke volume. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (CFPWV) and global cognitive function by using the Mini-Mental Short Examination (MMSE). Education level was determined by years of formal education.

Results: In linear regression analysis adjusting for age, sex, formal years of education and CFPWV, CI was significantly positively associated with MMSE (BETA = 0.344 0.130, p = 0.0082). In logistic regression analysis adjusting for age, sex, formal years of education and CFPWV, subjects with a CI 75 percentile had a significantly lower risk of low MMSE (<26) (OR = 0.495, 95% CI = 0.274–0.896, p = 0.02). In subgroup analysis, higher CI was significantly associated with higher MMSE and lower risk of low MMSE only in elders with 9 years of formal education. Causal mediation analysis suggests that higher CI maintains higher MMSE in elders with lower education levels whereas higher CFPWV causes lower MMSE in all elders.

Conclusion: In elders with normal ejection fraction, a higher CI was associated with a lower risk of cognitive function impairment, independent of arterial stiffness, mainly in subjects with a lower education level and possibly a smaller cognitive reserve.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S76 - S76
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.067How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Cheng Hao-Min
AU  - Chuang Shao-Yuan
AU  - Ko Yu-Ting
AU  - Liao Chao-Feng
AU  - Pan Wen-Harn
AU  - Liu Wen-Ling
AU  - Hung Chen-Ying
AU  - Chen Chen-Huan
PY  - 2020
DA  - 2020/02/15
TI  - P35 Education Level may Modify the Association Between Cardiac Index and Cognitive Function Among Elders with Normal Ejection Function
JO  - Artery Research
SP  - S76
EP  - S76
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.067
DO  - 10.2991/artres.k.191224.067
ID  - Hao-Min2020
ER  -