P36 Leukocyte Telomere Length is Inversely Associated with Wave Reflection in 566 Normotensive and Never-treated Hypertensive Subjects

Ilkka Pörsti; Milja Honkonen; Kati Vääräniemi; Outi Saijonmaa; Antti Tikkakoski; Jenni Koskela; Arttu Eräranta; Mika Kähönen; Jukka Mustonen; Frej Fyhrquist

doi:10.2991/artres.k.191224.068

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Volume 25, Issue Supplement 1, December 2019, Pages S77 - S77

P36 Leukocyte Telomere Length is Inversely Associated with Wave Reflection in 566 Normotensive and Never-treated Hypertensive Subjects

Authors

Ilkka Pörsti¹^{, 2}^{, *}, Milja Honkonen¹, Kati Vääräniemi¹, Outi Saijonmaa³, Antti Tikkakoski¹, Jenni Koskela¹^{, 2}, Arttu Eräranta¹, Mika Kähönen¹, Jukka Mustonen¹, Frej Fyhrquist³

¹Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

²Clinic of Internal Medicine, Tampere University Hospital, Tampere, Finland

³Minerva Institute for Medical Research, Biomedicum U2 Helsinki, 00290 Helsinki, Finland

^*Corresponding author. Email: ilkka.porsti@tuni.fi

Corresponding Author

Ilkka Pörsti

Available Online 15 February 2020.

DOI: 10.2991/artres.k.191224.068 How to use a DOI?
Abstract: Background: Telomeres are short segments in chromosome ends, the length of which is reduced during cell life-cycles. We examined the association of leukocyte telomere length and short telomere proportion with hemodynamic variables.

Methods: Altogether 566 subjects (279 women and 287 men) without cardiovascular disease and medications with direct cardiovascular influences were subjected supine recordings for 5 minutes. Haemodynamics were captured using continuous tonometric pulse wave analysis and whole-body impedance cardiography. The analyses were adjusted for age, body mass index (BMI), alcohol use, smoking, plasma chemistry, and estimated glomerular filtration rate (eGFR).

Results: In univariate analyses, leukocyte telomere length correlated with age, BMI, eGFR, aortic blood pressure, augmentation index, pulse wave velocity, and systemic vascular resistance (p < 0.05 for all). Short telomere proportion correlated with age, BMI, eGFR, aortic systolic blood pressure, augmentation index, and pulse wave velocity (p < 0.05 for all). In linear regression analyses of all hemodynamic variables, leukocyte telomere length was only an independent explanatory factor for augmentation index (Beta −0.006, p = 0.032), while short telomere proportion was not an explanatory factor for any of the hemodynamic variables, in contrast to age, BMI and several cardiovascular risk factors.

Conclusion: Augmentation index was predominantly related with chronological aging, but also with leukocyte telomere length, suggesting that this variable of central wave reflection is a moderate marker of vascular biological aging.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S77 - S77
Publication Date: 2020/02/15
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.068 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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ris enw bib

TY  - JOUR
AU  - Ilkka Pörsti
AU  - Milja Honkonen
AU  - Kati Vääräniemi
AU  - Outi Saijonmaa
AU  - Antti Tikkakoski
AU  - Jenni Koskela
AU  - Arttu Eräranta
AU  - Mika Kähönen
AU  - Jukka Mustonen
AU  - Frej Fyhrquist
PY  - 2020
DA  - 2020/02/15
TI  - P36 Leukocyte Telomere Length is Inversely Associated with Wave Reflection in 566 Normotensive and Never-treated Hypertensive Subjects
JO  - Artery Research
SP  - S77
EP  - S77
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.068
DO  - 10.2991/artres.k.191224.068
ID  - Pörsti2020
ER  -

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