Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S79 - S79

P38 Association of Daytime Augmentation Index with Brain-derived Neurotrophic Factor in Untreated Hypertensive Patients

Authors
János Nemcsik1, *, Dóra Batta1, Beáta Kőrösi1, Zsófia Nemcsik-Bencze2, Andrea László3, Lilla Lénárt4, Andrea Fekete
1Semmelweis University, Department of Family Medicine, Budapest, Hungary
2Semmelweis University, Magnetic Resonance Research Center, Budapest, Hungary
3First German Hospital for Traditional Chinese Medicine, Bad Kötzting, Germany
4MTA-SE “Lendület” Diabetes Research Group Budapest, Budapest, Hungary
*Corresponding author. Email: janos.nemcsik@gmail.com
Corresponding Author
János Nemcsik
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.070How to use a DOI?
Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophic molecule with impact on microvasculature and also with complex psychosomatic connections. The aim of our study was to evaluate its associations with 24-hour brachial and central hemodynamic parameters and arterial stiffness in untreated patients who were studied because of elevated office blood pressure. Mobil-O-Graph was used to measure the 24-hour brachial and central parameters. Serum BDNF was measured with ELISA, depression and anxiety were evaluated with questionnaires (Beck Depression Inventory and Hamilton Anxiety Scale, respectively). 73 patients were involved into the study. The average serum BDNF level was 28610 ± 7965 pg/ml. SeBDNF was correlated with daytime augmentation index (Aix, r = 0.234, p = 0.046). A borderline correlation was found with 24-hour total peripheral resistance (r = 0.227, p = 0.053). In multiple linear regression model the association between Aix and BDNF remained significant after the adjustment for age, depression and anxiety (B = 0.243, p = 0.034), but was attenuated after further adjustment for total vascular resistance (B = 0.186, p = 0.106). In conclusions, the impact of BDNF on microvasculature can have physiological importance as through the mediation of total vascular resistance it can influence pulse wave reflection.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S79 - S79
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.070How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - János Nemcsik
AU  - Dóra Batta
AU  - Beáta Kőrösi
AU  - Zsófia Nemcsik-Bencze
AU  - Andrea László
AU  - Lilla Lénárt
AU  - Andrea Fekete
PY  - 2020
DA  - 2020/02/15
TI  - P38 Association of Daytime Augmentation Index with Brain-derived Neurotrophic Factor in Untreated Hypertensive Patients
JO  - Artery Research
SP  - S79
EP  - S79
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.070
DO  - 10.2991/artres.k.191224.070
ID  - Nemcsik2020
ER  -