Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S67 - S67

P24 Restored Physiological Local Carotid Pulse Wave Velocity After Bariatric Surgery in Obese Subjects

Authors
Alessandro Giudici1, *, Carmela Morizzo2, Michaela Kozakova3, Lorenzo Losso2, Carlo Palombo2, Kennedy J. Cruickshank4, Ashraf Khir1
1Biomedical Engineering Research Theme, Brunel University London, Uxbridge, UK
2Department of Surgical, Medical, Molecular Pathology and Critical Area Medicine, University of Pisa, Pisa, Italy
3Esaote SpA, Florence, Italy
4School of Life-Course/Nutritional Sciences, King's College, St. Thomas' & Guy's Hospitals, London, UK
*Corresponding author. Email: alessandro.giudici@brunel.ac.uk
Corresponding Author
Alessandro Giudici
Available Online 15 February 2020.
DOI
10.2991/artres.k.191224.058How to use a DOI?
Abstract

Obesity is a risk factor for cardiovascular events and is associated with increased arterial stiffness [1,2]. However, the effect of drastic changes in Body Mass Index (BMI) on arterial mechanics has not been fully investigated. Our study aimed at evaluating changes in local carotid PWV (cPWV) in obese patients before and 6 months after bariatric surgery. N = 20 obese subjects free of cardiovascular events and diabetes (44 ± 9 years, 5 men, BMI = 48.8 ± 7.5 kg/m2) undergoing bariatric surgery were recruited in the Pisa University Hospital (Italy). Flow and diameter waveforms were acquired by ultrasound scanner (Aloka Alpha10, Hitachi Group, Japan) (1 kHz) at the right common carotid artery at baseline, after a 32.4 ± 7.6 days diet period, and 6.5 ± 2.7 months post-intervention. The lnDU-loop method was used for the estimation of cPWV [3]. Basal cPWV was 6.05 ± 1.21 m/s. The 1-month diet period produced a 2 kg/m2 reduction in BMI, while cPWV decreased by approx. 0.6 m/s. 6–7 months after bariatric surgery, BMI dropped to 35.3 ± 6.5 kg/m2 and cPWV furtherly decreased of approx. 0.9 m/s reaching a mean value of 4.57 ± 1.02 m/s (76% of the basal value) (Figure 1). Bariatric surgery and the consequent intensive weight loss produced a significant decrease of arterial stiffness and restored cPWV to physiological values of age-matched healthy subjects [4]. The fast reversal of increased arterial stiffness suggests a functional mechanism possibly related to a reduced haemodynamic load. Moreover, while having a small effect on the BMI, 1-month diet regulation effectively decreased cPWV by 10%, possibly indicating the short-term positive effects of a healthy lifestyle on haemodynamics.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S67 - S67
Publication Date
2020/02/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.058How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Alessandro Giudici
AU  - Carmela Morizzo
AU  - Michaela Kozakova
AU  - Lorenzo Losso
AU  - Carlo Palombo
AU  - Kennedy J. Cruickshank
AU  - Ashraf Khir
PY  - 2020
DA  - 2020/02/15
TI  - P24 Restored Physiological Local Carotid Pulse Wave Velocity After Bariatric Surgery in Obese Subjects
JO  - Artery Research
SP  - S67
EP  - S67
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.058
DO  - 10.2991/artres.k.191224.058
ID  - Giudici2020
ER  -