P44 Spureous Systolic Hypertension or a Defined Arterial Stiffness Phenotype

DOI

10.2991/artres.k.191224.075How to use a DOI?

Abstract

Background: High systolic blood pressure in young individuals with normal central pressure has been described as “Spureous Systolic Hypertension” and there is a strong controversy if it is a normal or pathologic condition.

Objective: To compare young adult patients (20–40 y.o.) with isolated systolic hypertension (ISH) with elderly patients (60 to 80 y.o.) with the same condition and analyze the vascular and hemodynamic patterns to find out if the spureous hypertension is truly a hypertensive phenotype and deserves to be treated.

Material and Methods: To analyze the vascular pattern we evaluated the database of NIVE (Phillips IU22^® and CAP with Arteriograph^®) with 2890 first ever evaluated patients, and analyzed 55 young controls (A), 56 young with ISH (B), 19 elderly controls (C) and 51 elderly with ISH (D). For the Hemodynamic analysis (Impedance Cardiography, Exxer^®) the same groups with (A) 115, (B) 59, (C) 50 and (D) 148.

Results: Most of the vascular and hemodynamic findings as expected by age but Group B was similar in terms of the central stiffness (PWV, Ao PP and total Compliance) to the group C meaning EVA. The proportion of p with increased IMT, abnormal PWV and endothelial dysfunction were higher in the B group compared with A and the elderly (Comparison between same age intervals by “t” test and ANOVA for the whole sample. Signification <0.05).

Conclusion: Young hypertensives between 20 and 40 y.o. with ISH seem to be carriers of a defined arterial stiffness hypertensive phenotype rather than an “innocent” spureous phenomena.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Pedro Forcada
AU  - Miguel Sangiovanni
AU  - Wanda Pampinella
AU  - Oscar Montaña
PY  - 2020
DA  - 2020/02/15
TI  - P44 Spureous Systolic Hypertension or a Defined Arterial Stiffness Phenotype
JO  - Artery Research
SP  - S84
EP  - S84
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.075
DO  - 10.2991/artres.k.191224.075
ID  - Forcada2020
ER  -