5.2 Arterial Stiffness and Periodontitis: A Systematic Review and Meta-Analysis

Christelle Darnaud; Alexandre Courtet; Audrey Schmitt; Clotilde Carra; Pierre Boutouyrie; Philippe Bouchard

doi:10.2991/artres.k.191224.031

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Volume 25, Issue Supplement 1, December 2019, Pages S38 - S38

5.2 Arterial Stiffness and Periodontitis: A Systematic Review and Meta-Analysis

Authors

Christelle Darnaud¹^{, 2}^{, *}, Alexandre Courtet², Audrey Schmitt², Clotilde Carra², Pierre Boutouyrie¹, Philippe Bouchard²

¹Paris Cardiovascular Research Center, UMR-S970, Department of Epidemiology, Paris, France

²Rothschild Hospital, AP-HP, Paris 7/Denis Diderot University, Paris, France

^*Corresponding author. Email: chd839@gmail.com

Corresponding Author

Christelle Darnaud

Available Online 15 February 2020.

DOI: 10.2991/artres.k.191224.031 How to use a DOI?
Abstract: Background: Despite a large number of studies linking cardiovascular diseases and periodontitis (Buhlin et al. 2011; Hansen et al. 2016; Pussinen et al. 2003), few studies make it possible to draw accurate conclusions on the link between periodontitis and arterial stiffness. Endothelial cells maintain vascular homeostasis but are affected by inflammatory injuries (Lacolley et al. 2017). Periodontal diseases involve bacteria-induced inflammation of the tissues supporting the teeth (Tomás et al. 2012), inducing endothelial dysfunction. We conducted a systematic review from existing studies for answering the following questions: (1) Do periodontitis patients have impaired arterial stiffness compared to controls? (2) Is periodontal treatment effective to improve pulse wave velocity (PWV) values?

Methods: A systematic review of the literature, focusing on measurements of PWV in periodontitis patients, was conducted by two independent reviewers. The literature search was done until June 2019. Risk of bias was independently assessed. All clinical studies reporting PWV in patients with severe periodontitis were retrieved for full-text evaluation.

Results: Final selection included 16 studies for qualitative analysis and 10 studies for quantitative analysis (meta-regression analysis). The results show that patients with severe periodontitis have increased PWV compared to controls (PWV mean difference 0.81 m/s; 95% CI: 0.56–1.06; p < 0.00001). This concerns both carotid to femoral, brachial ankle and carotid radial PWV. However, we were unable to identify a positive effect of periodontal treatment on PWV value.

Conclusion: This systematic review and meta-analysis support an association between severe periodontitis and PWV.
Copyright: © 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

References

[1]K Buhlin, P Mäntylä, S Paju, JS Peltola, MS Nieminen, J Sinisalo, et al., Periodontitis is associated with angiographically verified coronary artery disease, J Clin Periodontol, Vol. 38, 2011, pp. 1007-14.

[2]GM Hansen, A Egeberg, P Holmstrup, and PR Hansen, Relation of periodontitis to risk of cardiovascular and all-cause mortality (from a Danish nationwide cohort study), Am J Cardiol, Vol. 118, 2016, pp. 489-93.

[3]P Lacolley, V Regnault, P Segers, and S Laurent, Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease, Physiol Rev, Vol. 97, 2017, pp. 1555-617.

[4]PJ Pussinen, P Jousilahti, G Alfthan, T Palosuo, S Asikainen, and V Salomaa, Antibodies to periodontal pathogens are associated with coronary heart disease, Arterioscler Thromb Vasc Biol, Vol. 23, 2003, pp. 1250-4.

[5]I Tomás, P Diz, A Tobias, C Scully, and N Donos, Periodontal health status and bacteraemia from daily oral activities: systematic review/meta-analysis, J Clin Periodontol, Vol. 39, 2012, pp. 213-28.

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S38 - S38
Publication Date: 2020/02/15
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.031 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Christelle Darnaud
AU  - Alexandre Courtet
AU  - Audrey Schmitt
AU  - Clotilde Carra
AU  - Pierre Boutouyrie
AU  - Philippe Bouchard
PY  - 2020
DA  - 2020/02/15
TI  - 5.2 Arterial Stiffness and Periodontitis: A Systematic Review and Meta-Analysis
JO  - Artery Research
SP  - S38
EP  - S38
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.031
DO  - 10.2991/artres.k.191224.031
ID  - Darnaud2020
ER  -

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